Stress and Sleep Study

NCT ID: NCT05218109

Last Updated: 2024-04-04

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-09

Study Completion Date

2023-05-29

Brief Summary

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This between-subject, longitudinal pilot study in healthy college students aims to explore the acceptability and preliminary outcomes of two novel and complementary interventions that may improve stress and sleep: transcutaneous vagus nerve stimulation (tVNS) and a mobile mindfulness intervention.

Detailed Description

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Conditions

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Stress, Psychological Sleep Transcutaneous Electric Nerve Stimulation Vagus Nerve Stimulation Mindfulness

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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tVNS + mindfulness

Transcutaneous vagus nerve stimulation plus behavioral: mindfulness

Group Type EXPERIMENTAL

tVNS

Intervention Type DEVICE

transcutaneous vagus nerve stimulation

Mindfulness

Intervention Type BEHAVIORAL

Brightmind mobile mindfulness application

Sham + mindfulness

Sham transcutaneous vagus nerve stimulation plus behavioral: mindfulness

Group Type SHAM_COMPARATOR

Mindfulness

Intervention Type BEHAVIORAL

Brightmind mobile mindfulness application

sham tVNS

Intervention Type DEVICE

sham transcutaneous vagus nerve stimulation

Mindfulness only

Group Type ACTIVE_COMPARATOR

Mindfulness

Intervention Type BEHAVIORAL

Brightmind mobile mindfulness application

Control

Control number puzzle task delivered via mobile device

Group Type ACTIVE_COMPARATOR

Number Puzzle

Intervention Type OTHER

Control number puzzle task delivered via mobile device

Interventions

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tVNS

transcutaneous vagus nerve stimulation

Intervention Type DEVICE

Mindfulness

Brightmind mobile mindfulness application

Intervention Type BEHAVIORAL

sham tVNS

sham transcutaneous vagus nerve stimulation

Intervention Type DEVICE

Number Puzzle

Control number puzzle task delivered via mobile device

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Undergraduate student (ages 18-30)
* Must own a smartphone
* Must be able to read and write English

Exclusion Criteria

* Major medical illnesses including diagnosed severe neurological illnesses (e.g., stroke, seizure history), medical conditions associated with neurological effects (e.g. heart, kidney disease), autoimmune disorders, and severe psychiatric diseases (e.g., schizophrenia)
* Pregnancy
* History of brain surgery, tumor, intracranial metal implantation, pacemakers or other implanted devices
* History of adverse reaction to electrical nerve stimulation
* Prescribed sleep medications and/or psychotropic medications
* Illicit or prescription drug abuse within the last two months (marijuana or alcohol abuse \>2 weeks out will be acceptable for inclusion)
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sarah Bottari, M.S.

Role: PRINCIPAL_INVESTIGATOR

University of Florida

Liva LaMontagne, Dr. Psych.

Role: PRINCIPAL_INVESTIGATOR

University of Florida

Locations

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University of Florida

Gainesville, Florida, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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IRB202101724

Identifier Type: -

Identifier Source: org_study_id

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