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CytOSorb TreatMent Of Critically Ill PatientS Registry

NCT ID: NCT05146336

Last Updated: 2025-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

3000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-22

Study Completion Date

2032-09-30

Brief Summary

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Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based resource to measure and improve the quality of patient care

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Detailed Description

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Conditions

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Septic Shock Acute Respiratory Distress Syndrome Trauma Rhabdomyolysis Cardiogenic Shock Pancreatitis Acute on Chronic Liver Failure Acute Liver Failure Burns Chimeric Antigen Receptor T-Cell Therapy (CAR-T) Cytokine Release Syndrome (CRS) Extracorporeal Life Support Postoperative Endocarditis Hemophagocytic Lymphohistiocytoses Liver Transplant; Complications Infectious Disease Postoperative Vasoplegic Syndrome Drug Overdose Sepsis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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CytoSorb

Sorbent hemoperfusion system

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Planned OR actual CytoSorb® 300 mL device utilization
2. Informed consent for prospective registry participation

Exclusion Criteria

1. Use of the CytoSorb® 300 mL device for antithrombotic removal only
2. Intraoperative use of CytoSorb® 300 mL device during cardiac surgery only
3. The occurrence of a complication or other medically justified circumstance that arises after written informed consent has been obtained from the patient and before or during the planned therapy and as a result of which the use of CytoSorb® 300 mL Adsorber is contraindicated or no longer appropriate.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CytoSorbents, Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ricard Ferrer Roca, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Vall d'Hebron

Locations

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Klinikum Klagenfurt am Wörthersee

Klagenfurt, , Austria

Site Status RECRUITING

Medizinische Universität Wien

Vienna, , Austria

Site Status RECRUITING

Universitätsklinikum Aachen

Aachen, , Germany

Site Status RECRUITING

Herz- und Diabeteszentrum Nordrhein-Westfalen

Bad Oeynhausen, , Germany

Site Status RECRUITING

Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Bochum

Bochum, , Germany

Site Status RECRUITING

Katholisches Klinikum Bochum, St. Josef-Hospital

Bochum, , Germany

Site Status RECRUITING

Universitätsklinikum Essen, Medizinische Intensivtherapie

Essen, , Germany

Site Status RECRUITING

Universitätsklinikum Essen, Nephrologie

Essen, , Germany

Site Status RECRUITING

Universitätsklinikum Essen, Thorax- und Kardiovaskuläre Chirurgie

Essen, , Germany

Site Status RECRUITING

Universitätsmedizin Göttingen, Allgemein-, Viszeral- und Kinderchirurgie

Göttingen, , Germany

Site Status RECRUITING

Universitätsmedizin Göttingen, Herzzentrum Göttingen

Göttingen, , Germany

Site Status RECRUITING

Klinikum Herford

Herford, , Germany

Site Status RECRUITING

Universitätsklinikum Jena

Jena, , Germany

Site Status RECRUITING

Klinikum Kassel

Kassel, , Germany

Site Status WITHDRAWN

Universitätsklinikum Marburg

Marburg, , Germany

Site Status RECRUITING

Kliniken Maria Hilf

Mönchengladbach, , Germany

Site Status TERMINATED

Deutsches Herzzentrum München

München, , Germany

Site Status RECRUITING

LMU Klinikum München

München, , Germany

Site Status RECRUITING

Klinikum Oldenburg

Oldenburg, , Germany

Site Status RECRUITING

Helios Dr. Horst Schmidt Kliniken Wiesbaden

Wiesbaden, , Germany

Site Status RECRUITING

Ospedale Pediatrico Bambino Gesù

Roma, , Italy

Site Status TERMINATED

IRCCS Ospedale Casa Sollievo della Sofferenza

San Giovanni Rotondo, , Italy

Site Status RECRUITING

SP ZOZ Szpital Uniwersytecki w Krakowie

Krakow, , Poland

Site Status RECRUITING

Uniwersyteckim Spitalem Klinicznym im. Jana Mikulicza - Radeckiego we Wrocławiu

Wroclaw, , Poland

Site Status RECRUITING

Unidade Local de Saúde de Coimbra E.P.E

Coimbra, , Portugal

Site Status RECRUITING

ULS São José, Hospital Curry Cabral

Lisbon, , Portugal

Site Status RECRUITING

Hospital Universitari Vall d'Hebron

Barcelona, Barcelona, Spain

Site Status RECRUITING

Hospital Juan Ramón Jimenez

Huelva, , Spain

Site Status RECRUITING

Countries

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Austria Germany Italy Poland Portugal Spain

Central Contacts

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Robert Wilke

Role: CONTACT

[email protected]
+49 30 654 99 145

References

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Taccone FS, Brunkhorst FM, Bottari G, Hidalgo J, Kribben A, Teboul JL, Tomescu D, Klaus T, Scheier J, Deliargyris E, Ferrer R. The COSMOS Registry of CytoSorb Hemoadsorption Therapy in Critically Ill Patients: Protocol for an International, Prospective Registry. JMIR Res Protoc. 2024 Nov 5;13:e55880. doi: 10.2196/55880.

Reference Type DERIVED
PMID: 39500494 (View on PubMed)

Other Identifiers

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O06

Identifier Type: -

Identifier Source: org_study_id

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