Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Total Enrollment
533 participants
Study Classification
OBSERVATIONAL
Study Start Date
2018-01-08
Study Completion Date
2019-02-28
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
This pilot-study will be a prospective, single-centre, observational study including 100 critically ill patients consecutively admitted to the medical intensive care unit (ICU) of the University hospital of Zurich, Switzerland, to assess and validate the use of MR-proADM and the CT-proET1/MR-proADM-ratio as prognostic markers in critically ill patients.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Evaluation of an ICU-specific Questionnaire for Patient-reported Outcome Measures
NCT02767180
Intensive Care Unit Syndrome
COMPLETED
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
NCT07242027
Sepsis
Respiratory Failure
Cardiac Arrest
+3 more
COMPLETED
CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.
NCT05633290
Heart Failure
Myocarditis
Sepsis
+1 more
UNKNOWN
The Critical Care Recovery Program: Use of a Structured Clinic Visit to Reduce Adverse Drug Events in ICU Survivors
NCT06723860
Post Intensive Care Syndrome (PICS)
Polypharmacy
Adverse Drug Events
+1 more
NOT_YET_RECRUITING
ICU Trial in Critical Ill COVID-19 Patients
NCT04349982
Risk Factor, Cardiovascular
Covid19
Critical Illness
+1 more
COMPLETED
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
This pilot-study will be a prospective, single-centre, observational study including 100 critically ill patients consecutively admitted to the medical intensive care unit (ICU) of the University hospital of Zurich, Switzerland, to assess and validate the use of MR-proADM and the CT-proET1/MR-proADM-ratio as prognostic markers in critically ill patients. After obtaining informed consent of the patient or approval of a legal representative and meeting of the inclusion, as well as missing exclusion criteria the patients will be enrolled.
At study enrolment patient health status will be assessed by health related diagnosis and the Charlson comorbidity index. This information is obtained routinely in every patient in our ICU. The Charlson comorbidity index is calculated based on the medical history of the patient. The values of MR-proADM and CT-proET-1 will be measured daily over the first 7 days of the ICU stay. If a patient is discharged before day 7, no further measurements will be performed. The blood samples will be collected together with the routine blood check on admission, as well as each morning. Clinical evaluation of the patients will take place each morning including the evaluation of the hemodynamics, organ dysfunction, microcirculation and the need for vasopressors.
The severity of illness of the patient will be assessed using the SAPS II score and the SOFA score. SAPS-II reflects the physiological status of the patient within the first 24 hours (admission severity) and the SOFA score the number of failing organs (respiration, coagulation, liver, cardiovascular, CNS, renal). The SAPS-II will be assessed on Visit 3 and the SOFA daily using the information obtained during the routine clinical examination and the laboratory results of the day. SAPS II and SOFA scores are part of the routine assessment of all our patients in the ICU and are used as quality indicators.
The status of the microcirculation is assessed using clinical signs (mottling score, capillary refill time and sublingual microcirculation functional status) and laboratory parameters reflecting the degree of tissue oxygen extraction such as SaO2-SvO2 gap, Pv-aCO2 gap and the arterial lactate concentration. All these parameters are delivered by the blood gas analyser located in the ICU from an arterial and a venous blood sample of 1.5 ml each drawn via the arterial and central venous line respectively. These catheters and blood samples are part of the routine hemo-dynamic monitoring and assessment of the critically ill patient in our ICU.
The patients' survival status will be assessed on day 7 and day 28 after study enrolment. In addition, ICU and hospital mortality are recorded. If the patient is still in the hospital on day 28, survival data will be taken from the medical record. In the case the patient is dismissed from the hospital the study team will contact him by phone call. If he is not reachable (documented attempts) the study team will contact his general practitioner. To be in line with data protection requirements the patient gives the consent to contact the general practitioner in the informed consent form. No other information than the survival status will be collected at this stage. Data collection for the study ends 28 (± 3 days) days after enrolment.
At study enrolment patient health status will be assessed by health related diagnosis and the Charlson comorbidity index. This information is obtained routinely in every patient in our ICU. The Charlson comorbidity index is calculated based on the medical history of the patient. The values of MR-proADM and CT-proET-1 will be measured daily over the first 7 days of the ICU stay. If a patient is discharged before day 7, no further measurements will be performed. The blood samples will be collected together with the routine blood check on admission, as well as each morning. Clinical evaluation of the patients will take place each morning including the evaluation of the hemodynamics, organ dysfunction, microcirculation and the need for vasopressors.
The severity of illness of the patient will be assessed using the SAPS II score and the SOFA score. SAPS-II reflects the physiological status of the patient within the first 24 hours (admission severity) and the SOFA score the number of failing organs (respiration, coagulation, liver, cardiovascular, CNS, renal). The SAPS-II will be assessed on Visit 3 and the SOFA daily using the information obtained during the routine clinical examination and the laboratory results of the day. SAPS II and SOFA scores are part of the routine assessment of all our patients in the ICU and are used as quality indicators.
The status of the microcirculation is assessed using clinical signs (mottling score, capillary refill time and sublingual microcirculation functional status) and laboratory parameters reflecting the degree of tissue oxygen extraction such as SaO2-SvO2 gap, Pv-aCO2 gap and the arterial lactate concentration. All these parameters are delivered by the blood gas analyser located in the ICU from an arterial and a venous blood sample of 1.5 ml each drawn via the arterial and central venous line respectively. These catheters and blood samples are part of the routine hemo-dynamic monitoring and assessment of the critically ill patient in our ICU.
The patients' survival status will be assessed on day 7 and day 28 after study enrolment. In addition, ICU and hospital mortality are recorded. If the patient is still in the hospital on day 28, survival data will be taken from the medical record. In the case the patient is dismissed from the hospital the study team will contact him by phone call. If he is not reachable (documented attempts) the study team will contact his general practitioner. To be in line with data protection requirements the patient gives the consent to contact the general practitioner in the informed consent form. No other information than the survival status will be collected at this stage. Data collection for the study ends 28 (± 3 days) days after enrolment.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Acute Phase Biomarkers
Medical ICU Admitted Patients
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Observational Model Type
COHORT
Study Time Perspective
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Medical ICU Patients
All patients admitted to the medical intensive care unit of the University hospital of Zurich during the recruitment period
Blood sampling for MR-proADM & CT-proET-1
Intervention Type
DIAGNOSTIC_TEST
Collection of at most 8 blood samples (3ml each) per Patient admitted to the study and sampling for MR-proADM \& CT-proET-1
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Blood sampling for MR-proADM & CT-proET-1
Collection of at most 8 blood samples (3ml each) per Patient admitted to the study and sampling for MR-proADM \& CT-proET-1
Intervention Type
DIAGNOSTIC_TEST
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* All patients admitted to the medical intensive care unit of the University hospital of Zurich during the recruitment period
* Male and female participants ≥ 18 years
* Written informed consent by the participant after information about the research project or if the patient is incapable of giving informed consent, a legal representative has confirmed the presumed will of the participant (according Art. 15 KlinV emergency patients)
* Male and female participants ≥ 18 years
* Written informed consent by the participant after information about the research project or if the patient is incapable of giving informed consent, a legal representative has confirmed the presumed will of the participant (according Art. 15 KlinV emergency patients)
Exclusion Criteria
* Inability of the conscious patients to follow the experimental procedure, e.g. because of insufficient language skills (German), mental illness, dementia etc.
* Pregnancy
* Participation in ongoing clinical trials of other departments of the University Hospital Zurich
* Pregnancy
* Participation in ongoing clinical trials of other departments of the University Hospital Zurich
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
ThermoFisher Scientific Brahms Biomarkers France
INDUSTRY
Sponsor Role
collaborator
University of Zurich
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Responsibility Role
SPONSOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Marco Maggiorini, MD
Role: PRINCIPAL_INVESTIGATOR
University Zürich/ University Hospital Zürich
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University Hospital Zurich, Medical intensive care unit
Zurich, Canton of Zurich, Switzerland
Site Status
Countries
Review the countries where the study has at least one active or historical site.
Switzerland
References
Explore related publications, articles, or registry entries linked to this study.
Espana PP, Capelastegui A, Quintana JM, Bilbao A, Diez R, Pascual S, Esteban C, Zalacain R, Menendez R, Torres A. Validation and comparison of SCAP as a predictive score for identifying low-risk patients in community-acquired pneumonia. J Infect. 2010 Feb;60(2):106-13. doi: 10.1016/j.jinf.2009.11.013. Epub 2009 Dec 2.
Reference Type
BACKGROUND
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402.
Reference Type
BACKGROUND
Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, Lewis SA, Macfarlane JT. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax. 2003 May;58(5):377-82. doi: 10.1136/thorax.58.5.377.
Reference Type
BACKGROUND
Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818-29.
Reference Type
BACKGROUND
Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993 Dec 22-29;270(24):2957-63. doi: 10.1001/jama.270.24.2957.
Reference Type
BACKGROUND
Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001 Oct 10;286(14):1754-8. doi: 10.1001/jama.286.14.1754.
Reference Type
BACKGROUND
Vincent JL, de Mendonca A, Cantraine F, Moreno R, Takala J, Suter PM, Sprung CL, Colardyn F, Blecher S. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med. 1998 Nov;26(11):1793-800. doi: 10.1097/00003246-199811000-00016.
Reference Type
BACKGROUND
Pierrakos C, Vincent JL. Sepsis biomarkers: a review. Crit Care. 2010;14(1):R15. doi: 10.1186/cc8872. Epub 2010 Feb 9.
Reference Type
BACKGROUND
Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev. 2000 Apr;21(2):138-67. doi: 10.1210/edrv.21.2.0396.
Reference Type
BACKGROUND
Eto T. A review of the biological properties and clinical implications of adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP), hypotensive and vasodilating peptides. Peptides. 2001 Nov;22(11):1693-711. doi: 10.1016/s0196-9781(01)00513-7.
Reference Type
BACKGROUND
Morgenthaler NG, Struck J, Alonso C, Bergmann A. Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem. 2005 Oct;51(10):1823-9. doi: 10.1373/clinchem.2005.051110. Epub 2005 Aug 11.
Reference Type
BACKGROUND
Papassotiriou J, Morgenthaler NG, Struck J, Alonso C, Bergmann A. Immunoluminometric assay for measurement of the C-terminal endothelin-1 precursor fragment in human plasma. Clin Chem. 2006 Jun;52(6):1144-51. doi: 10.1373/clinchem.2005.065581. Epub 2006 Apr 20.
Reference Type
BACKGROUND
Albrich WC, Dusemund F, Ruegger K, Christ-Crain M, Zimmerli W, Bregenzer T, Irani S, Buergi U, Reutlinger B, Mueller B, Schuetz P. Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm. BMC Infect Dis. 2011 May 3;11:112. doi: 10.1186/1471-2334-11-112.
Reference Type
BACKGROUND
Albrich WC, Ruegger K, Dusemund F, Schuetz P, Arici B, Litke A, Blum CA, Bossart R, Regez K, Schild U, Guglielmetti M, Conca A, Schafer P, Schubert M, de Geest S, Reutlinger B, Irani S, Burgi U, Huber A, Muller B. Biomarker-enhanced triage in respiratory infections: a proof-of-concept feasibility trial. Eur Respir J. 2013 Oct;42(4):1064-75. doi: 10.1183/09031936.00113612. Epub 2013 Jan 24.
Reference Type
BACKGROUND
Bello S, Lasierra AB, Minchole E, Fandos S, Ruiz MA, Vera E, de Pablo F, Ferrer M, Menendez R, Torres A. Prognostic power of proadrenomedullin in community-acquired pneumonia is independent of aetiology. Eur Respir J. 2012 May;39(5):1144-55. doi: 10.1183/09031936.00080411. Epub 2011 Nov 10.
Reference Type
BACKGROUND
Christ-Crain M, Morgenthaler NG, Stolz D, Muller C, Bingisser R, Harbarth S, Tamm M, Struck J, Bergmann A, Muller B. Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]. Crit Care. 2006;10(3):R96. doi: 10.1186/cc4955. Epub 2006 Jun 28.
Reference Type
BACKGROUND
Christ-Crain M, Morgenthaler NG, Struck J, Harbarth S, Bergmann A, Muller B. Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study. Crit Care. 2005;9(6):R816-24. doi: 10.1186/cc3885. Epub 2005 Nov 15.
Reference Type
BACKGROUND
Courtais C, Kuster N, Dupuy AM, Folschveiller M, Jreige R, Bargnoux AS, Guiot J, Lefebvre S, Cristol JP, Sebbane M. Proadrenomedullin, a useful tool for risk stratification in high Pneumonia Severity Index score community acquired pneumonia. Am J Emerg Med. 2013 Jan;31(1):215-21. doi: 10.1016/j.ajem.2012.07.017. Epub 2012 Sep 20.
Reference Type
BACKGROUND
Daka B, Olausson J, Larsson CA, Hellgren MI, Rastam L, Jansson PA, Lindblad U. Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: a longitudinal observational study in the Vara-Skovde Cohort. BMC Cardiovasc Disord. 2015 Nov 14;15:146. doi: 10.1186/s12872-015-0141-y.
Reference Type
BACKGROUND
Guignant C, Voirin N, Venet F, Lepape A, Monneret G. Persistent high level of circulating midregional-proadrenomedullin and increased risk of nosocomial infections after septic shock. J Trauma Acute Care Surg. 2012 Jan;72(1):293-6. doi: 10.1097/TA.0b013e31823a0d23.
Reference Type
BACKGROUND
Huang DT, Angus DC, Kellum JA, Pugh NA, Weissfeld LA, Struck J, Delude RL, Rosengart MR, Yealy DM. Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia. Chest. 2009 Sep;136(3):823-831. doi: 10.1378/chest.08-1981. Epub 2009 Apr 10.
Reference Type
BACKGROUND
Liu D, Xie L, Zhao H, Liu X, Cao J. Prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with community-acquired pneumonia: a systematic review and meta-analysis. BMC Infect Dis. 2016 May 26;16:232. doi: 10.1186/s12879-016-1566-3.
Reference Type
BACKGROUND
Lundberg OH, Bergenzaun L, Ryden J, Rosenqvist M, Melander O, Chew MS. Adrenomedullin and endothelin-1 are associated with myocardial injury and death in septic shock patients. Crit Care. 2016 Jun 9;20(1):178. doi: 10.1186/s13054-016-1361-y.
Reference Type
BACKGROUND
Schuetz P, Christ-Crain M, Morgenthaler NG, Struck J, Bergmann A, Muller B. Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis. Endothelium. 2007 Nov-Dec;14(6):345-51. doi: 10.1080/10623320701678326.
Reference Type
BACKGROUND
Schuetz P, Christ-Crain M, Zimmerli W, Mueller B. Repeated measurements of endothelin-1 precursor peptides predict the outcome in community-acquired pneumonia. Intensive Care Med. 2011 Jun;37(6):970-80. doi: 10.1007/s00134-011-2208-2. Epub 2011 Mar 11.
Reference Type
BACKGROUND
Schuetz P, Stolz D, Mueller B, Morgenthaler NG, Struck J, Mueller C, Bingisser R, Tamm M, Christ-Crain M. Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia. BMC Infect Dis. 2008 Feb 28;8:22. doi: 10.1186/1471-2334-8-22.
Reference Type
BACKGROUND
Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83. doi: 10.1016/0021-9681(87)90171-8.
Reference Type
BACKGROUND
Champion HR, Sacco WJ, Carnazzo AJ, Copes W, Fouty WJ. Trauma score. Crit Care Med. 1981 Sep;9(9):672-6. doi: 10.1097/00003246-198109000-00015.
Reference Type
BACKGROUND
Fleming S, Gill P, Jones C, Taylor JA, Van den Bruel A, Heneghan C, Thompson M. Validity and reliability of measurement of capillary refill time in children: a systematic review. Arch Dis Child. 2015 Mar;100(3):239-49. doi: 10.1136/archdischild-2014-307079. Epub 2014 Sep 26.
Reference Type
BACKGROUND
Ait-Oufella H, Bige N, Boelle PY, Pichereau C, Alves M, Bertinchamp R, Baudel JL, Galbois A, Maury E, Guidet B. Capillary refill time exploration during septic shock. Intensive Care Med. 2014 Jul;40(7):958-64. doi: 10.1007/s00134-014-3326-4. Epub 2014 May 9.
Reference Type
BACKGROUND
Ait-Oufella H, Lemoinne S, Boelle PY, Galbois A, Baudel JL, Lemant J, Joffre J, Margetis D, Guidet B, Maury E, Offenstadt G. Mottling score predicts survival in septic shock. Intensive Care Med. 2011 May;37(5):801-7. doi: 10.1007/s00134-011-2163-y. Epub 2011 Mar 4.
Reference Type
BACKGROUND
Coudroy R, Jamet A, Frat JP, Veinstein A, Chatellier D, Goudet V, Cabasson S, Thille AW, Robert R. Incidence and impact of skin mottling over the knee and its duration on outcome in critically ill patients. Intensive Care Med. 2015 Mar;41(3):452-9. doi: 10.1007/s00134-014-3600-5. Epub 2014 Dec 17.
Reference Type
BACKGROUND
Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, Schortgen F, Lasocki S, Veber B, Dehoux M, Bernard M, Pasquet B, Regnier B, Brun-Buisson C, Chastre J, Wolff M; PRORATA trial group. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet. 2010 Feb 6;375(9713):463-74. doi: 10.1016/S0140-6736(09)61879-1. Epub 2010 Jan 25.
Reference Type
BACKGROUND
Assink-de Jong E, de Lange DW, van Oers JA, Nijsten MW, Twisk JW, Beishuizen A. Stop Antibiotics on guidance of Procalcitonin Study (SAPS): a randomised prospective multicenter investigator-initiated trial to analyse whether daily measurements of procalcitonin versus a standard-of-care approach can safely shorten antibiotic duration in intensive care unit patients--calculated sample size: 1816 patients. BMC Infect Dis. 2013 Apr 16;13:178. doi: 10.1186/1471-2334-13-178.
Reference Type
BACKGROUND
Safdar N, Fine JP, Maki DG. Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection. Ann Intern Med. 2005 Mar 15;142(6):451-66. doi: 10.7326/0003-4819-142-6-200503150-00011.
Reference Type
BACKGROUND
American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005 Feb 15;171(4):388-416. doi: 10.1164/rccm.200405-644ST. No abstract available.
Reference Type
BACKGROUND
De Backer D, Hollenberg S, Boerma C, Goedhart P, Buchele G, Ospina-Tascon G, Dobbe I, Ince C. How to evaluate the microcirculation: report of a round table conference. Crit Care. 2007;11(5):R101. doi: 10.1186/cc6118.
Reference Type
BACKGROUND
Pranskunas A, Koopmans M, Koetsier PM, Pilvinis V, Boerma EC. Microcirculatory blood flow as a tool to select ICU patients eligible for fluid therapy. Intensive Care Med. 2013 Apr;39(4):612-9. doi: 10.1007/s00134-012-2793-8. Epub 2012 Dec 20.
Reference Type
BACKGROUND
Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM; Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. 2008 Dec;34(12):2210-7. doi: 10.1007/s00134-008-1193-6. Epub 2008 Jul 2.
Reference Type
BACKGROUND
Hilty MP, Pichler J, Ergin B, Hefti U, Merz TM, Ince C, Maggiorini M. Assessment of endothelial cell function and physiological microcirculatory reserve by video microscopy using a topical acetylcholine and nitroglycerin challenge. Intensive Care Med Exp. 2017 Dec;5(1):26. doi: 10.1186/s40635-017-0139-0. Epub 2017 May 18.
Reference Type
BACKGROUND
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
proADM
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Assessment of Red Cell Distribution Width's Prognostic Ability in Septic Intensive Care Unit Patients
NCT06847451
COMPLETED
Diagnostic Value of sTREM-1 and PCT Level as Well as CPIS Score for Ventilator-Associated Pneumonia Among ICU Sepsis Patients
NCT01406951
COMPLETED
CytOSorb TreatMent Of Critically Ill PatientS Registry
NCT05146336
RECRUITING
Health and Quality of Life One Year After Discharge From the Intensive Care Unit (ICU)
NCT02671916
TERMINATED
Mean Systemic Filling Pressure and Heart Performance Predicting Fluid Responsiveness in Sepsis
NCT02778633
UNKNOWN
ESICM UNITE COVID-19 Project (UNITE-COVID)
NCT04836065
COMPLETED
COVID-19 Patients Admitted to the ICU
NCT04816786
UNKNOWN
Fluid Administration and Fluid Accumulation in the Intensive Care Unit
NCT06258616
RECRUITING
Prognostic Value of CD64 Marker for Patients in Intensive Care Unit
NCT03617796
UNKNOWN
Infection Surveillance in Intensive Care Patients
NCT00197847
UNKNOWN
PREdiction of DIagnosed Covid-19 infecTion in IUC Patients
NCT04327180
COMPLETED
Anti-pyretic Therapy in Critically Ill Adults
NCT01173367
COMPLETED
PHASE2
Outcomes of Patients With COVID-19 in the Intensive Care Unit
NCT04336345
COMPLETED
Biomarker of Lung Injury in ARDS Patients Receiving ECMO Support
NCT01967602
UNKNOWN
MONITOR-IC: Determining and Improving Long-term Consequences of ICU Care
NCT03246334
RECRUITING
Prospective Observational Cohort Study of Critically Ill Patients With Covid-19 in Sweden
NCT04382417
COMPLETED
Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill
NCT04755777
COMPLETED
Characteristics of Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection (COVID-19)
NCT04948242
UNKNOWN
Efficacy of ICU-VTE Scale in ICU Patients
NCT05487066
COMPLETED
Recovery After ICU Treatment: A Prospective Cohort Study
NCT02599428
COMPLETED
Procalcitonin to Guide Obtaining Bloodcultures in the ICU Intensive Care Infection Score
NCT01847079
COMPLETED
NA
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
NCT03622632
UNKNOWN
ICU Background Early Awareness for Critical deterioratiON
NCT07119411
NOT_YET_RECRUITING
Multiple Biomarkers in ICU Sepsis Patients
NCT03802136
UNKNOWN
The Blood Pressure Analysis on Critically Ill Patients
NCT03827369
UNKNOWN