Comparison of Nitrofurantoin and Calcium Hydroxide as Intracanal Medicaments in Alleviating Post-operative Pain
NCT ID: NCT04900571
Last Updated: 2021-05-25
Study Results
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Basic Information
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COMPLETED
PHASE4
60 participants
INTERVENTIONAL
2021-01-01
2021-05-18
Brief Summary
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Detailed Description
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60 patients were randomly divided into 3 groups, each group having 20 patients as following: Group 1: Nitrofurantoin, Group 2: Calcium Hydroxide and Group 3: Control. Preoperative pain was recorded using a numerical pain scale. After access preparation, chemomechanical preparation was performed with subsequent placement of intracanal medicaments. Pre-operative pain score was initially recorded, followed by Post-operative pain at 12, 24, 48, and 72 hours, respectively. Root canal treatment was performed in single root teeth with patients suffering from symptomatic irreversible pulpitis.
Total of 20 patients were randomized into 3 groups. Majority of the patients in all 3 groups initially presented with moderate to severe pre-operative pain. After 72 Hours post-operatively, 50% patients in group 1 reported no pain, while 5% patients in both group 2 and 3 had no pain. Pain significantly subsided in group 1 as compared to group 2 and 3. Regarding age and gender, both had no significant relationship with the pain scores in all of the 3 groups.
Nitrofurantoin has been proven to be an effective intracanal medicament in alleviating immediate post-operative pain in patients with symptomatic irreversible pulpitis as compared to calcium hydroxide. While the control group with no intracanal medicament showed little reduction in pain scores. So, nitrofurantoin can be used as a substitute to currently available standard intracanal medicaments.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Nitrofurantoin
Measuring pain score using numerical pain scale post-operatively at different time intervals.
Nitrofurantoin 100 MG
Comparison of alleviating post-operative pain between nitrofurantoin and calcium hydroxide
Calcium Hydroxide
Measuring pain score using numerical pain scale post-operatively at different time intervals.
Nitrofurantoin 100 MG
Comparison of alleviating post-operative pain between nitrofurantoin and calcium hydroxide
Control
Measuring pain score using numerical pain scale post-operatively at different time intervals.
Nitrofurantoin 100 MG
Comparison of alleviating post-operative pain between nitrofurantoin and calcium hydroxide
Interventions
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Nitrofurantoin 100 MG
Comparison of alleviating post-operative pain between nitrofurantoin and calcium hydroxide
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* no age restrictions
* no history of allergy to medications used in root canal treatment
* patients suffering from Symptomatic Irreversible Pulpitis
Exclusion Criteria
* multirooted teeth
ALL
Yes
Sponsors
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Altamash Institute of Dental Medicine
OTHER
Responsible Party
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Hira Abbasi
Principal Investigator
Principal Investigators
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Hira Abbasi, BDS, FCPS II Trainee
Role: PRINCIPAL_INVESTIGATOR
Altamash Institute of Dental Medicine, Pakistan
Locations
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Altamash Institute of Dental Medicine
Karachi, Sindh, Pakistan
Countries
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Other Identifiers
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Nitrofurantoin Vs CaOH
Identifier Type: -
Identifier Source: org_study_id
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