The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
NCT ID: NCT06207253
Last Updated: 2025-05-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE2/PHASE3
48 participants
INTERVENTIONAL
2025-11-30
2025-12-31
Brief Summary
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The main question\[s\] it aims to answer are:
• Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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High concentration of diclofenac sodium
High concentration of diclofenac sodium mixed with saline
Diclofenac Sodium
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Low concentration of diclofenac sodium
Low concentration of diclofenac sodium mixed with saline
Diclofenac Sodium
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Calcium hydroxide
Calcium hydroxide paste form
Calcium hydroxide
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Interventions
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Diclofenac Sodium
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Calcium hydroxide
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Eligibility Criteria
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Inclusion Criteria
* Periapical Index (PAI) ≥ 2
* The teeth are restorable
Exclusion Criteria
* Non restorable teeth
* Medically compromised patients with systemic complication that would alter the treatment.
* Teeth with internal/external root resorption
* Patient with an allergy to diclofenac sodium
18 Years
50 Years
ALL
Yes
Sponsors
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British University In Egypt
OTHER
Responsible Party
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Summer Elsayed
Principle Investigator
Principal Investigators
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Shehab Eldin M Saber, doctoral
Role: STUDY_DIRECTOR
british university in Egypt- dentistry collage
Locations
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British university in Egypt
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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23-039
Identifier Type: -
Identifier Source: org_study_id
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