Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants
NCT ID: NCT05306431
Last Updated: 2023-02-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
60 participants
INTERVENTIONAL
2022-06-01
2022-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Polyhexamethylene biguanide
Polyhexamethylene biguanide (PHMB), is a disinfectant solution having a broad spectrum of antimicrobial activity and is investigated as an endodontic irrigant. It is non-corrosive, non-toxic and acts by disrupting cell membrane integrity. PHMB 0.2% has been recently used as a root canal irrigant in vitro and has shown promising results of antimicrobial effectiveness of \> 99.9% for both PHMB and Sodium hypochlorite
Polyhexamethylene biguanide
Polyhexamethylene biguanide (PHMB), is a disinfectant solution having a broad spectrum of antimicrobial activity and is investigated as an endodontic irrigant
Sodium Hypochloride
A number of irrigant solution has thus been proposed to serve the purpose, the most popular being sodium hypochlorite (NaOCl) because of its excellent antimicrobial activity but also the ability to dissolve organic matter.
Sodium Hypochlorite
A number of irrigant solution has thus been proposed to serve the purpose, the most popular being sodium hypochlorite (NaOCl) because of its excellent antimicrobial activity but also the ability to dissolve organic matter
Interventions
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Polyhexamethylene biguanide
Polyhexamethylene biguanide (PHMB), is a disinfectant solution having a broad spectrum of antimicrobial activity and is investigated as an endodontic irrigant
Sodium Hypochlorite
A number of irrigant solution has thus been proposed to serve the purpose, the most popular being sodium hypochlorite (NaOCl) because of its excellent antimicrobial activity but also the ability to dissolve organic matter
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Both male and female patients
* Periodontally healthy teeth as determined by Periodontal Probing
* Patients with non-vital necrotic pulps as determined by Cold Test
* Patients with acute apical periodontitis determined by history and clinical examination
* Clinical Findings:
Visual: Carious tooth decay Occlusion: Hyperocclusion Pulp vitality test: Negative Periapical radiograph: Caries involving pulp space and PDL widening Percussion Test: Positive Palpation Test: Negative
• Single rooted teeth as determined radiographically
Exclusion Criteria
* Teeth undergoing Re-endo treatments
* Teeth with root fractures and/ non restorable determined by clinical and radiographic examination
* Patients receiving antibiotic treatment in the past 3 months determined by history
* Patient with Diabetes determined by history
* Patient with history of smoking
18 Years
50 Years
ALL
Yes
Sponsors
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Altamash Institute of Dental Medicine
OTHER
Responsible Party
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Hira Abbasi
Principal Investigator
Locations
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Hira Danish
Karachi, Sindh, Pakistan
Countries
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Other Identifiers
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Root canal Irrigiant
Identifier Type: -
Identifier Source: org_study_id
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