The Effectiveness of Phytotherapy in SARS-COV2(COVID-19)

NCT ID: NCT04851821

Last Updated: 2023-01-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-01-04
• Study Completion Date: 2021-06-30

Brief Summary

Quercetin is one of the flavonoids. Quercetin as well as rutin are recognized to be among the most active of the flavonoids. It is to quercetin that several medicinal plants, including ginkgo and St. John's Wort, owe part of their therapeutic effects. Often combined with vitamin C in supplements, it improves absorption by the body and delays its elimination.

Quercetin is extracted from a variety of plant sources, including the onion peel and seeds and pods of Dimorphandra mollis, a tree in the legume family native to South America.

At present, there is no scientific data to demonstrate the effectiveness of herbal medicine, regardless of the plant, to prevent or treat COVID-19. On the other hand, some plant-based food supplements have anti-inflammatory or immunomodulatory properties that may disrupt inflammatory defense mechanisms useful in fighting infections, and in particular against COVID-19.

Detailed Description

Type of study: a randomized, double-blind study using the Quercetine in the treatment of patients with SARS COV2 (covid-19) Quercetin is extracted from a variety of plant sources, including the onion peel and the seeds and pods of Dimorphandra mollis, a legume tree native to South America.

Although we are far from knowing everything about quercetin, its antioxidant, anti-inflammatory, and antihistamine (antiallergic) properties have been observed in numerous in vitro and animal studies.

History on quercetin In 1937, Albert Szent-Gyorgyi received a Nobel Prize for discovering vitamin C and flavonoids, as well as for exploring their biochemical properties. Originally, he gave the flavonoids the name "vitamin P" because of their effectiveness in reducing the permeability of blood vessels. This name was abandoned when it was realized that these substances were not really vitamins.

Conditions

a Randomized Double-blind Study; Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2); PHYTOTHERAPIE

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Quercetix group

Each patient included, after signing the consent, will have a treatment for ten days: one tablet twice a day 30 minutes before the meal.

Group Type: EXPERIMENTAL

Quercetin

Intervention Type: DRUG

Each patient included, after signing the consent, will have a treatment for ten days: one tablet times three per day 30 minutes before the meal.

Placebo Group

Each patient included, after signing the consent, will have a treatment for ten days: one tablet twice a day 30 minutes before the meal.

Group Type: PLACEBO_COMPARATOR

Quercetin

Intervention Type: DRUG

Each patient included, after signing the consent, will have a treatment for ten days: one tablet times three per day 30 minutes before the meal.

Interventions

Quercetin

Each patient included, after signing the consent, will have a treatment for ten days: one tablet times three per day 30 minutes before the meal.

Intervention Type: DRUG

Other Intervention Names

PLACEBO

Eligibility Criteria

Inclusion Criteria

• all patients attending the emergency department for influenza-like illness.
• Being over 18 years old

Exclusion Criteria

• Any patient requiring admission
• Non-consenting patients

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hôpital Universitaire Sahloul

OTHER

Sponsor Role: lead

Responsible Party

Riadh Boukef

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Riadh Boukef, professor

Role: PRINCIPAL_INVESTIGATOR

CHU Sahloul, Sousse, Tunisia

Locations

Riadh Boukef

Sahloul, Sousse Governorate, Tunisia

Countries

Tunisia

Other Identifiers

Quercetix

Identifier Type: -

Identifier Source: org_study_id