Effect of Quercetin on Prophylaxis and Treatment of COVID-19

NCT ID: NCT04377789

Last Updated: 2021-02-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

447 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-03-20

Study Completion Date

2020-08-31

Brief Summary

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Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. The investigators hypothesize that quercetin, as a strong scavenger and anti-inflammatory agent, can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Detailed Description

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Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. Quercetin is reported to be effective on treatment and prophylaxis of other SARS like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events. Upon this data, the investigators hypothesize that quercetin can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Conditions

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COVID-19

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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non-quercetin group

Participants, who accept to enroll the study without having quercetin prophylaxis and who do not have a history of COVID-19, will be in this group.

Group Type NO_INTERVENTION

No interventions assigned to this group

quercetin prophylaxis group

Participants, who takes a daily dose of 500mg quercetin and who not have a history of COVID-19, will be in this group.

Group Type ACTIVE_COMPARATOR

Quercetin Prophylaxis

Intervention Type DIETARY_SUPPLEMENT

a daily dose of quercetin (500mg) will be taken by non-COVID-19 intervention group 1

quercetin treatment group

Participants, who takes a daily dose of 1000mg quercetin and who are proven cases for COVID-19, will be in this group.

Group Type ACTIVE_COMPARATOR

Quercetin Treatment

Intervention Type DIETARY_SUPPLEMENT

a daily dose of quercetin (1000mg) will be taken by proven COVID-19 cases intervention group 2

Interventions

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Quercetin Prophylaxis

a daily dose of quercetin (500mg) will be taken by non-COVID-19 intervention group 1

Intervention Type DIETARY_SUPPLEMENT

Quercetin Treatment

a daily dose of quercetin (1000mg) will be taken by proven COVID-19 cases intervention group 2

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* moderate-high risk for COVID-19
* obtained informed consent

Exclusion Criteria

* declined to participate
* genetic/chromosomal abnormalities
* any kind of sensitivity or allergy for quercetin
* history of previous hypersensitivity with quercetin
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Orbiteratec (funding)

UNKNOWN

Sponsor Role collaborator

Kanuni Sultan Suleyman Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hasan Onal

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Kanuni Sultan Suleyman Training and Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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KSSEAH--0058

Identifier Type: -

Identifier Source: org_study_id

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