The Effect of Quercetin in Sarcoidosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Study Completion Date

2006-01-31

Brief Summary

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The exact cause of the chronic lung disease sarcoidosis is still unknown. Consequently, a complete efficacious treatment is still not available. Earlier studies indicate an important key role for oxidative stress, i.e. an imbalance between the production of and the protection against ROS, in the etiology of sarcoidosis. Antioxidants, needed for protection against ROS, are indeed lower in sarcoidosis. Therefore, antioxidant therapy to strengthen the reduced antioxidant defense might be efficacious in sarcoidosis treatment. Since ROS are also capable of initiating and mediating inflammation, antioxidant therapy might also mitigate the elevated inflammation that occurs in sarcoidosis. The flavonoid quercetin possesses both anti-oxidative and anti-inflammatory capacities and might therefore serve as a good candidate for antioxidant therapy in sarcoidosis.

Therefore, the aim of the present study is to determine the effect of quercetin supplementation in sarcoidosis patients on markers of both oxidative stress and inflammation.

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Detailed Description

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Conditions

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Sarcoidosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type OTHER

2

quercetin (food supplement)

Group Type ACTIVE_COMPARATOR

quercetin

Intervention Type DIETARY_SUPPLEMENT

1000 mg quercetin within 24 hours

Interventions

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quercetin

1000 mg quercetin within 24 hours

Intervention Type DIETARY_SUPPLEMENT

placebo

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis of sarcoidosis with emphasize on pulmonary sarcoidosis
* no smoking
* no treatment

Exclusion Criteria

* clinical diagnosis (and treatment) of other diseases
* symptoms of sarcoidosis in other organs besides the lung
* use of food supplements or vitamins

Eligible Sex

ALL

Accepts Healthy Volunteers

No