Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise in Coronary Paths

NCT ID: NCT06095635

Last Updated: 2023-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-10

Study Completion Date

2023-09-30

Brief Summary

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Introduction: Most cardiovascular diseases (CVD) can be prevented and controlled by adopting lifestyle changes, such as regular physical exercise and nutrition. Resveratrol and beverage extract promote beneficial health effects due to their nutritional properties. Objective: to analyze the effects of resveratrol supplementation and withdrawal extract on post-exercise recovery in coronary heart disease patients. Methods: men diagnosed with ischemic coronary artery disease will undergo four exercise protocols consisting of 30 minutes of aerobic exercise on an ergometric treadmill, with 5 minutes of warm-up, intensity of 30% of the heart rate reserve (HRR), followed by 25 minutes at intensity 60% of FCR and for a final 30 minutes of recovery in the supine position. Before each exercise protocol, all volunteers will consume: 500 mg of placebo (starch), or 500 mg of beetroot, or 500 mg of resveratrol and will also consume resveratrol and drink (500 mg each) 30 minutes before exercise. , the order of each supplementation will be done randomly. Cardiorespiratory parameters and heart rate variability (HRV) will be assessed at different times throughout the experimental procedure. To analyze the moments (rest versus recovery), the Bonferroni post-test will be used for parametric distribution or the Dunn post-test for non-parametric distribution. Statistical significance will be calculated at 5% for all analyses.

Detailed Description

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Conditions

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Coronary Artery Disease Autonomic Nervous System Disease Blood Pressure Heart Rate

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo Protocol

exercise and placebo capsules 500 mg (starch)

Group Type PLACEBO_COMPARATOR

Placebo Protocol

Intervention Type OTHER

ingestion of 500 mg of starch following 30 minutes of exercise (treadmill)

Protocol Beet

exercise and beet extract 500 mg

Group Type EXPERIMENTAL

Protocol Beet

Intervention Type OTHER

ingestion of 500 mg of beet extect following 30 minutes of exercise (treadmill)

Protocol Resveratrol

exercise and resveratrol capsules 500 mg

Group Type EXPERIMENTAL

Protocol Resveratrol

Intervention Type OTHER

ingestion of 500 mg of resveratrol following 30 minutes of exercise (treadmill)

Protocol Beet and Resveratrol

exercise and beet extract 500mg and resveratrol capsules 500 mg

Group Type EXPERIMENTAL

Protocol Beet and Resveratrol

Intervention Type OTHER

ingestion 500 mg of beet extect and 500 mg of resveratrol following 30 minutes of exercise (treadmill)

Interventions

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Placebo Protocol

ingestion of 500 mg of starch following 30 minutes of exercise (treadmill)

Intervention Type OTHER

Protocol Beet

ingestion of 500 mg of beet extect following 30 minutes of exercise (treadmill)

Intervention Type OTHER

Protocol Resveratrol

ingestion of 500 mg of resveratrol following 30 minutes of exercise (treadmill)

Intervention Type OTHER

Protocol Beet and Resveratrol

ingestion 500 mg of beet extect and 500 mg of resveratrol following 30 minutes of exercise (treadmill)

Intervention Type OTHER

Other Intervention Names

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500 mg of starch 500 mg of beet extract 500 mg of resveratrol 500 mg of beet extect and 500 mg of resveratrol

Eligibility Criteria

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Inclusion Criteria

* adult men over 45 years of age
* diagnosed with ischemic coronary artery disease and with preserved left ventricular function (above 50%), confirmed by a previous echocardiogram

Exclusion Criteria

Volunteers who present at least one of the following characteristics will be excluded:

* smokers
* alcohol drinkers
* those who did not attend a cardiovascular rehabilitation program for at least 3 months prior to data collection
* individuals who have known infections, metabolic and respiratory diseases that could interfere in cardiac autonomic control, unstable angina, uncontrolled hypertension, significant valvular disease, uncontrolled metabolic disease (e.g., uncontrolled diabetes and thyroid disease)
Minimum Eligible Age

40 Years

Maximum Eligible Age

79 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Universidade Estadual Paulista Júlio de Mesquita Filho

OTHER

Sponsor Role lead

Responsible Party

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Luana Almeida Gonzaga

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Universidade Estadual Paulista

Presidente Prudente, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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UEPJMG

Identifier Type: -

Identifier Source: org_study_id

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