Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function
NCT ID: NCT04920799
Last Updated: 2025-04-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
24 participants
INTERVENTIONAL
2021-11-12
2026-05-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Study Groups
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Nitrate rich beetroot juice
Nitrate rich beetroot juice
Participants will drink nitrate rich beetroot juice (2.4 floz ; Beet It Sport Nitrate 400 concentrated beetroot shot; James White Drink, ltd) twice daily for two weeks.
Nitrate depleted beetroot juice
Nitrate depleted beetroot juice
Participants will drink nitrate depleted beetroot juice (2.4 floz ; Beet It placebo concentrated beetroot shot; James White Drink, ltd) twice daily for two weeks.
Interventions
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Nitrate rich beetroot juice
Participants will drink nitrate rich beetroot juice (2.4 floz ; Beet It Sport Nitrate 400 concentrated beetroot shot; James White Drink, ltd) twice daily for two weeks.
Nitrate depleted beetroot juice
Participants will drink nitrate depleted beetroot juice (2.4 floz ; Beet It placebo concentrated beetroot shot; James White Drink, ltd) twice daily for two weeks.
Eligibility Criteria
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Inclusion Criteria
* Considered to have stable CAD on optimal medical therapy
* 60 to 85 years of age
* Men and women (women must be postmenopausal either natural or surgical)
* Able to give consent
Exclusion Criteria
* Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months.
* Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant on-going or recurrent illness
* Individuals that have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months
* Uncontrolled hypertension
* Use of tobacco products including smoking traditional or e-cigarettes
* Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone)
* Regular aerobic exercise training
* Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation
* Unwilling to remain weight stable during study participation
60 Years
85 Years
ALL
No
Sponsors
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University of Florida
OTHER
Responsible Party
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Locations
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Integrative Cardiovascular Physiology Laboratory, University of Florida
Gainesville, Florida, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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IRB202100040
Identifier Type: -
Identifier Source: org_study_id
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