Dietary Nitrate and Healthy Older Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-12

Study Completion Date

2018-01-31

Brief Summary

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This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults. Participants will receive both a nitrate containing beetroot juice for 10 days and a nitrate depleted beetroot juice for 10 days

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Detailed Description

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A recent exciting finding is that dietary nitrate supplementation (in the form of beetroot juice) appears to reduce the amount of oxygen needed to complete moderate intensity walking in healthy, young individuals. Nitrate is known to be converted in the body to nitric oxide (NO), a substance which reduces blood pressure and may affect the energy-producing mechanisms inside muscle cells. Exercise tolerance and muscle function typically declines with age and nitrate supplementation therefore may help improve cardiovascular health and the ability to carry out low-intensity daily activities in aging populations. The purpose of this study is to see if healthy, elderly individuals benefit from beetroot juice intake similarly to the effects seen in young adults. If this is indeed the case, then it may suggest that dietary supplementation with a relatively cheap, widely available, and natural food product may improve the ability of healthy elderly individuals to undergo everyday tasks and ultimately improve their quality of life.

Conditions

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Blood Pressure Cognitive Change Functional Capacity Brain Metabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Nitrate-rich beetroot juice

2 x 70mL concentrated juice per day for 10 days

Group Type ACTIVE_COMPARATOR

Nitrate-rich beetroot juice

Intervention Type DIETARY_SUPPLEMENT

concentrated beetroot juice

Nitrate-depleted beetroot juice

2 x 70mL concentrated juice per day for 10 days

Group Type PLACEBO_COMPARATOR

Nitrate-depleted beetroot juice

Intervention Type DIETARY_SUPPLEMENT

concentrated beetroot juice

Interventions

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Nitrate-rich beetroot juice

concentrated beetroot juice

Intervention Type DIETARY_SUPPLEMENT

Nitrate-depleted beetroot juice

concentrated beetroot juice

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

1. 70 - 80 years of age
2. male or female

Exclusion Criteria

1. involved in regular structured exercise
2. receiving medication for:

* pulmonary conditions
* cardiovascular conditions
* metabolic conditions
* musculoskeletal conditions
* ulcerative colitis
* renal disease

Minimum Eligible Age

70 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes