The Impact of Inorganic Nitrate-rich Beetroot Juice on Microvascular Blood Flow and Cognitive Function
NCT ID: NCT05810974
Last Updated: 2024-11-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2023-03-14
2023-08-07
Brief Summary
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The majority of beneficial effects with inorganic nitrate have been observed within young healthy populations. However, it is known that after the menopause women are at an increased risk of cardiovascular disease and have reduced levels of nitric oxide in their body; this could also contribute to the cognitive decline also observed post-menopause. This trial will investigate the impact of inorganic nitrate from beetroot juice on the blood flow in small blood vessels and on cognitive function in postmenopausal women. The hypothesis of the study is that the nitrate in beetroot juice will increase circulating nitric oxide that will then increase blood flow in small blood vessels and improve cognitive function.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Concentrated beetroot juice
Concentrated beetroot juice
Subjects will consume 70ml shot (Beet-it Sport nitrate 400 shot, James White Drinks) and this drink contains 0.4g inorganic nitrate
Nitrate depleted beetroot juice + potassium nitrate (KNO3)
Nitrate depleted beetroot juice + potassium nitrate (KNO3)
Nitrate-depleted beetroot juice (70ml) and 0.4g KNO3- will be mixed. (Same appearance and taste with Beet-it sport shot)
Nitrate-depleted beetroot juice
Nitrate depleted beetroot juice
Subjects will consume 70ml of (Beet-it Placebo shot, James White Drinks). This drink is the same as the Beet-it Sport nitrate shot but has the nitrate removed.
Interventions
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Concentrated beetroot juice
Subjects will consume 70ml shot (Beet-it Sport nitrate 400 shot, James White Drinks) and this drink contains 0.4g inorganic nitrate
Nitrate depleted beetroot juice + potassium nitrate (KNO3)
Nitrate-depleted beetroot juice (70ml) and 0.4g KNO3- will be mixed. (Same appearance and taste with Beet-it sport shot)
Nitrate depleted beetroot juice
Subjects will consume 70ml of (Beet-it Placebo shot, James White Drinks). This drink is the same as the Beet-it Sport nitrate shot but has the nitrate removed.
Eligibility Criteria
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Inclusion Criteria
* Able to understand information sheet and willing to comply with the study protocol and able to give informed consent
* Not having menstrual period for 12 months
Exclusion Criteria
* Medical history of myocardial infarction, angina, thrombosis, stroke, cancer, high cholesterol, liver, renal, respiratory or bowel diseases or diabetes or other endocrine disorder
* BMI\>30
* Any tobacco and/or nicotine users (or quit within the last 6 months)
* Current use of antihypertensive medication
* Alcohol intake \> 14 units/week
* Vigorous exercise \> 3 times/ week
* Antihypertensive medication users
* People who have had hysterectomy
* Currently taking hormone replacement therapy or selective oestrogen receptor modulator
45 Years
FEMALE
Yes
Sponsors
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University of Reading
OTHER
Responsible Party
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Charlotte E Mills
Lecturer, Principal investigator
Locations
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University of Reading
Reading, UK, United Kingdom
Countries
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Other Identifiers
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-TBC-
Identifier Type: -
Identifier Source: org_study_id
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