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Effects of Dietary Nitrate From Vegetable/Fruit Juice on Cerebral Blood Flow Parameters

NCT ID: NCT01169662

Last Updated: 2010-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2010-07-31

Brief Summary

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Nitrate provides the body with an alternative source of Nitric Oxide which plays a large role in promoting blood flow and reducing blood pressure. Nitrate supplementation with vegetable/fruit juice has recently been shown to reduce blood pressure and reduce energy expenditure during low intensity exercise. Such findings combined with the previously known biological effects of nitric oxide would suggest that nitrate supplementation would also impact on blood flow. The aim of this study is to examine the effects of dietary nitrate supplementation via vegetable/fruit juice drink on cerebral (brain) blood flow (using Near Infrared Spectroscopy).

Detailed Description

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Conditions

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Cerebrovascular Circulation Cognitive Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Vegetable/ Fruit juice

450ml active product, 45 ml no added sugar squash (for flavour)

Group Type ACTIVE_COMPARATOR

Vegetable/fruit juice

Intervention Type DIETARY_SUPPLEMENT

450ml active juice, 45ml no added sugar fruit squash (for flavour)

Placebo juice

Group Type PLACEBO_COMPARATOR

Placebo juice

Intervention Type DIETARY_SUPPLEMENT

50 ml No Added Sugar fruit squash, 45 ml Pressed Apple Juice, 405ml with water.

Interventions

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Vegetable/fruit juice

450ml active juice, 45ml no added sugar fruit squash (for flavour)

Intervention Type DIETARY_SUPPLEMENT

Placebo juice

50 ml No Added Sugar fruit squash, 45 ml Pressed Apple Juice, 405ml with water.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* healthy young (18-35 years) male and female adults, not vulnerable.

Exclusion Criteria

* smoke or consume any tobacco products (even occasionally)
* not proficient in English
* pregnant (or are seeking to become)
* currently taking recreational, over the counter/prescription medication (excluding the contraceptive pill), and/or dietary/herbal supplements.
* any food allergies or sensitivities that are relevant to the study
* history of/current head trauma, learning difficulties, ADHD, dyslexia, migraines or any gastric problems.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Northumbria University

OTHER

Sponsor Role lead

Responsible Party

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Northumbria University

Principal Investigators

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David Kennedy

Role: PRINCIPAL_INVESTIGATOR

Northumbria University

Locations

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Northumbria University

Newcastle upon Tyne, Tyne & Wear, United Kingdom

Site Status

Countries

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United Kingdom

References

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Wightman EL, Haskell-Ramsay CF, Thompson KG, Blackwell JR, Winyard PG, Forster J, Jones AM, Kennedy DO. Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation. Physiol Behav. 2015 Oct 1;149:149-58. doi: 10.1016/j.physbeh.2015.05.035. Epub 2015 May 31.

Reference Type DERIVED
PMID: 26037632 (View on PubMed)

Other Identifiers

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24AE1

Identifier Type: -

Identifier Source: org_study_id