Determination of the Independent Effects of Beetroot Juice Components, Dietary Nitrate and Antioxidants, on Exercise Tolerance and Health Benefits in Individuals With Obesity

NCT ID: NCT03545009

Last Updated: 2021-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-10

Study Completion Date

2020-08-30

Brief Summary

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The purpose of this study is to assess the effects of acute beetroot juice supplementation on exercise performance and cardiometabolic health in obese individuals with secondary cardiometabolic complications. Additionally, we will determine if the ergogenic health benefits of beetroot juice is due to the nitric oxide compound within the product, the antioxidant compound within the product, or a combination of the two compounds.

Detailed Description

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Conditions

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Metabolic Disease Obesity Exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Beetroot Juice

Group Type EXPERIMENTAL

Beetroot Juice

Intervention Type DIETARY_SUPPLEMENT

70ml Concentrated Beetroot Juice

Beetroot Juice no Nitrate

Group Type ACTIVE_COMPARATOR

Beetroot Juice no Nitrate

Intervention Type DIETARY_SUPPLEMENT

70ml Concentrated Beetroot Juice with nitrate removed

Sodium Nitrate

Group Type ACTIVE_COMPARATOR

Sodium Nitrate

Intervention Type DIETARY_SUPPLEMENT

70ml sodium nitrate, matched for nitrate concentration in Beetroot Juice arm

Control

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Sodium Nitrate

70ml sodium nitrate, matched for nitrate concentration in Beetroot Juice arm

Intervention Type DIETARY_SUPPLEMENT

Beetroot Juice no Nitrate

70ml Concentrated Beetroot Juice with nitrate removed

Intervention Type DIETARY_SUPPLEMENT

Beetroot Juice

70ml Concentrated Beetroot Juice

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* BMI ≥ 30 kg/m2
* Able to perform exercise testing on a cycle ergometer

Exclusion Criteria

* Currently taking medications know to affect cardiovascular or respiratory function
* Currently supplementing with an antioxidant compound
* Current smoker
* Currently taking antibiotics
* Not willing to abstain from mouthwash use
* Currently participating in regular physical activity
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Alabama at Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Gordon Fisher

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gordon Fisher, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Alabama at Birmingham

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Countries

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United States

Other Identifiers

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300001210

Identifier Type: -

Identifier Source: org_study_id

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