Nature of the Link Between Executive Functions and Theory of Mind in Multiple Sclerosis

NCT ID: NCT04806217

Last Updated: 2022-01-13

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-07-01
• Study Completion Date: 2024-01-01

Brief Summary

The purpose of this study is to explore inhibition and inference abilities in The Theory of Mind skills in multiple sclerosis patients using the Theory of Mind task.

Detailed Description

Multiple sclerosis is an autoimmune inflammatory disease of the central nervous system. It can cause lesions responsible for motor, ocular, sensory and cognitive symptoms.

The Theory of Mind and the primary facial emotions recognition (anger, joy, fear, surprise, sadness, disgust) are two processes of social cognition that play a role in the social interactions and social reasoning. The Theory of Mind is defined by the ability to understand the other person including thoughts, beliefs and desires that are unique and that may be different from our own.

In multiple sclerosis, difficulties in social cognition are associated with cognitive disorders, (even if the link with a deficit in executive functions remains debated). Indeed, when attributing a mental state to another person is needed,it is mandatory to put ourselves in the other person's place to adopt another perspective. Thus, several executive functions are required: working memory to maintain and manipulate several perspectives, flexibility to switch from one perspective to another one, and finally the inhibition of our own perspective to adopt the other's point of view.

The Theory of Mind's assessment uses nonverbal false belief task which assesses the ability to inhibit its own perspective to infer the mental state of another and the ability to change its perspective to adopt another's.

Thus, the purpose of this study is to explore inhibition and inference abilities in The Theory of Mind skills in multiple sclerosis patients using the Theory of Mind task.

Conditions

Multiple Sclerosis

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

¨Patients with multiple sclerosis

Patients :

• With multiple sclerosis
• Aged of 18 and over
• Recruited during their consultation in the adult outpatient unit or neurological unit or during a hospitalization.

Group Type: EXPERIMENTAL

Theory of Mind

Intervention Type: OTHER

Patients will be submitted to different neuropsychological tests used in routine and the non-verbal false belief task through in the Theory of Mind

Interventions

Theory of Mind

Patients will be submitted to different neuropsychological tests used in routine and the non-verbal false belief task through in the Theory of Mind

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

People :

• With multiple sclerosis
• Age ≥ 18 years old
• Not objecting to the use of their data

Exclusion Criteria

• Any associated neurological pathology or severe or chronic somatic disease (cancer)
• Visual and/or auditory disorders that do not allow for test taking
• Uncontrolled major psychiatric disorders
• Recent treatment with corticosteroids (less than 4 weeks before the evaluation)
• Patients under guardianship, curatorship or safeguard of justice
• Pregnant women

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Lille Catholic University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Bruno Lenne

Role: PRINCIPAL_INVESTIGATOR

Hôpital Saint Vincent de Paul, Lille

Central Contacts

Amélie Lansiaux, MD, PhD

Role: CONTACT

lansiaux.amelie@ghicl.net

03.20.22.52.69

Amel Boulafa

Role: CONTACT

boulafa.amel@ghicl.net

03.20.22.52.69

Other Identifiers

RC-P00109

Identifier Type: -

Identifier Source: org_study_id