Walking and Thinking - Brain Activity During Complex Walking in People With Multiple Sclerosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

41 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-04-21

Study Completion Date

2024-05-22

Brief Summary

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Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as Multiple Sclerosis (MS) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions.

The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecological valid state. The investigators aim therefore to explore brain function during complex walking in MS (in comparison with people with Parkinson's disease and healthy controls) by investigating the effects of neurological disease on motor-cognitive performance and its neural correlates during three conditions of complex walking (dual-task walking, navigation and a combination of both) using non-invasive measures of brain activity (functional near infrared spectrometry, fNIRS) and advanced gait analysis in real time in people with MS (in comparison with people with Parkinson's disease and healthy adults).

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Detailed Description

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Conditions

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Multiple Sclerosis Gait Disorders, Neurologic Neuro-Degenerative Disease Aging

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Multiple Sclerosis

People with Multiple Sclerosis, 18 years or older

No intervention

Intervention Type OTHER

Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.

1. Dual-task walking with the auditory stroop task.
2. Navigational walking - a course consisting of a distribution of 45 and 90 degrees turns to the left and right
3. Navigational and dual-task walking (condition 1 and 2 together)

Interventions

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No intervention

Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.

1. Dual-task walking with the auditory stroop task.
2. Navigational walking - a course consisting of a distribution of 45 and 90 degrees turns to the left and right
3. Navigational and dual-task walking (condition 1 and 2 together)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* with an MS diagnosis according to McDonald criteria
* with the ability to walk without a mobility device for ≥5 minutes continuously.