Effects of Probiotics and Nutritional Status on Exercise-Induced Symptoms, and Endurance Performance in Ultra-Endurance Athletes
NCT ID: NCT04779281
Last Updated: 2021-03-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2018-09-01
2019-05-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Oral Rehydration Salts supplemented with L. Rhamnosus GG
a supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, Lactobacillus Rhamnosus GG ATC53103 HN019 strain and fructooligosaccharides
Oral Rehydration Salts only
A supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, microcrystalline cellulose
Oral Rehydration Salts only
A supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, microcrystalline cellulose
Oral Rehydration Salts supplemented with L. Rhamnosus GG
A supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, Lactobacillus Rhamnosus GG ATC53103 HN019 strain and fructooligosaccharides
Interventions
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Oral Rehydration Salts supplemented with L. Rhamnosus GG
A supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, Lactobacillus Rhamnosus GG ATC53103 HN019 strain and fructooligosaccharides
Oral Rehydration Salts only
A supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, microcrystalline cellulose
Eligibility Criteria
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Inclusion Criteria
* Participants who do not have any metabolic disease,
* Have had at least one gastrointestinal symptom determined by using a Gastrointestinal Symptoms Rating Scale and Bristol Stool Chart Form Scale,
* Being a non-smoker,
* Have participated in at least one ultra-endurance race/event (lasts \> 4 hr),
* Taking no vitamins, minerals, dietary supplements, antibiotics, and any medication at least during the three months before the study,
* (For women) participants with a regular menstrual cycle of physiological length (24-35 days)
Exclusion Criteria
* Inability to adhere to any of the study protocol requirements (i.e. alcohol, caffeine consumption, diet control)
* Having consumed any supplements and/or medicines for the preceding 3 months period.
* (For women) participants in menopause or using oral contraceptives
20 Years
64 Years
ALL
No
Sponsors
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Istanbul Medeniyet University
OTHER
Responsible Party
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Asli Devrim Lanpir
Research Assistant, PhD
Principal Investigators
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Tuğba Kocahan, MD
Role: STUDY_DIRECTOR
Centre of Athlete Training and Health Research
Locations
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Centre of Athlete Training and Health Research
Ankara, , Turkey (Türkiye)
Countries
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References
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Krabak BJ, Lipman GS, Waite BL, Rundell SD. Exercise-Associated Hyponatremia, Hypernatremia, and Hydration Status in Multistage Ultramarathons. Wilderness Environ Med. 2017 Dec;28(4):291-298. doi: 10.1016/j.wem.2017.05.008. Epub 2017 Aug 7.
Nocella C, Cammisotto V, Pigozzi F, Borrione P, Fossati C, D'Amico A, Cangemi R, Peruzzi M, Gobbi G, Ettorre E, Frati G, Cavarretta E, Carnevale R; SMiLe Group. Impairment between Oxidant and Antioxidant Systems: Short- and Long-term Implications for Athletes' Health. Nutrients. 2019 Jun 15;11(6):1353. doi: 10.3390/nu11061353.
Pyne DB. Exercise-induced muscle damage and inflammation: a review. Aust J Sci Med Sport. 1994 Sep-Dec;26(3-4):49-58.
Lopez AA, Preziosi JP, Chateau P, Auguste P, Plique O. [Digestive disorders and self medication observed during a competition in endurance athletes. Prospective epidemiological study during a championship of triathlon]. Gastroenterol Clin Biol. 1994;18(4):317-22. French.
Maughan RJ, Shirreffs SM. Sports Beverages for Optimizing Physical Performance. In: Wilson T., Temple N. (eds) Beverage Impacts on Health and Nutrition. Nutrition and Health. Humana Press, Cham. 2016.
Mach N, Fuster-Botella D. Endurance exercise and gut microbiota: A review. J Sport Health Sci. 2017 Jun;6(2):179-197. doi: 10.1016/j.jshs.2016.05.001. Epub 2016 May 10.
Hoffman MD, Stellingwerff T, Costa RJS. Considerations for ultra-endurance activities: part 2 - hydration. Res Sports Med. 2019 Apr-Jun;27(2):182-194. doi: 10.1080/15438627.2018.1502189. Epub 2018 Jul 28.
Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science. 2001 May 11;292(5519):1115-8. doi: 10.1126/science.1058709.
Kekkonen RA, Vasankari TJ, Vuorimaa T, Haahtela T, Julkunen I, Korpela R. The effect of probiotics on respiratory infections and gastrointestinal symptoms during training in marathon runners. Int J Sport Nutr Exerc Metab. 2007 Aug;17(4):352-63. doi: 10.1123/ijsnem.17.4.352.
Martarelli D, Verdenelli MC, Scuri S, Cocchioni M, Silvi S, Cecchini C, Pompei P. Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training. Curr Microbiol. 2011 Jun;62(6):1689-96. doi: 10.1007/s00284-011-9915-3. Epub 2011 Mar 12.
Other Identifiers
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18-AKD-89
Identifier Type: OTHER
Identifier Source: secondary_id
KA-180011
Identifier Type: -
Identifier Source: org_study_id
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