Effect of a Proprietary Dietary Supplement on Fecal Volatile Organic Compounds

NCT ID: NCT02871596

Last Updated: 2017-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

27 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-08-31

Study Completion Date

2017-02-28

Brief Summary

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The purpose of the study is to determine the effects of both an anthocyanin-rich polyphenol blend and an anthocyanin-rich polyphenol blend combined with a prebiotic blend on fecal microbiota metabolism (assessed by gas chromatograph - mass spectrometry (GC-MS) headspace analysis) and fecal microbiota composition (assessed by next generation sequencing).

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo,Flavonoids,Flavonoids+Prebiotics

Participants will receive three treatments, for three weeks each, with 21 day washout period between each product.

Group Type EXPERIMENTAL

Placebo

Intervention Type OTHER

A combination of maltodextrins and red and blue food colors.

Flavonoids

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, and black rice extract.

Flavonoids+Prebiotics

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, black rice extract, inulin, and fructooligosaccharide.

Placebo,Flavonoids+Prebiotics,Flavonoids

Participants will receive three treatments, for three weeks each, with 21 day washout period between each product.

Group Type EXPERIMENTAL

Placebo

Intervention Type OTHER

A combination of maltodextrins and red and blue food colors.

Flavonoids

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, and black rice extract.

Flavonoids+Prebiotics

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, black rice extract, inulin, and fructooligosaccharide.

Flavonoids,Placebo,Flavonoids+Prebiotics

Participants will receive three treatments, for three weeks each, with 21 day washout period between each product.

Group Type EXPERIMENTAL

Placebo

Intervention Type OTHER

A combination of maltodextrins and red and blue food colors.

Flavonoids

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, and black rice extract.

Flavonoids+Prebiotics

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, black rice extract, inulin, and fructooligosaccharide.

Flavonoids,Flavonoids+Prebiotics,Placebo

Participants will receive three treatments, for three weeks each, with 21 day washout period between each product.

Group Type EXPERIMENTAL

Placebo

Intervention Type OTHER

A combination of maltodextrins and red and blue food colors.

Flavonoids

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, and black rice extract.

Flavonoids+Prebiotics

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, black rice extract, inulin, and fructooligosaccharide.

Flavonoids+Prebiotics,Placebo,Flavonoids

Participants will receive three treatments, for three weeks each, with 21 day washout period between each product.

Group Type EXPERIMENTAL

Placebo

Intervention Type OTHER

A combination of maltodextrins and red and blue food colors.

Flavonoids

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, and black rice extract.

Flavonoids+Prebiotics

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, black rice extract, inulin, and fructooligosaccharide.

Flavonoids+Prebiotics,Flavonoids,Placebo

Participants will receive three treatments, for three weeks each, with 21 day washout period between each product.

Group Type EXPERIMENTAL

Placebo

Intervention Type OTHER

A combination of maltodextrins and red and blue food colors.

Flavonoids

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, and black rice extract.

Flavonoids+Prebiotics

Intervention Type DIETARY_SUPPLEMENT

A combination of blueberry extract, black current extract, black rice extract, inulin, and fructooligosaccharide.

Interventions

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Placebo

A combination of maltodextrins and red and blue food colors.

Intervention Type OTHER

Flavonoids

A combination of blueberry extract, black current extract, and black rice extract.

Intervention Type DIETARY_SUPPLEMENT

Flavonoids+Prebiotics

A combination of blueberry extract, black current extract, black rice extract, inulin, and fructooligosaccharide.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male or female of any race or ethnicity between 18 to 70 years of age, inclusive;
* Body mass index (BMI) between 20 - 32 inclusive;
* Non-smoking status;
* Willing to consume assigned dietary supplements for a total of 6 weeks;
* Have access to email and a digital camera or camera phone.

Exclusion Criteria

* Age \<18 or \>70 years;
* BMI \<20 or \>32;
* Uncontrolled hypertension defined as diastolic blood pressure ≥95 mm Hg or systolic blood pressure ≥160 mm Hg;
* Self-reported presence of atherosclerotic disease and/or cardiopulmonary disease;
* Renal, hepatic, endocrine, gastrointestinal or other systemic disease;
* For women, pregnancy, breast feeding or postpartum less than 6 months;
* Current participation in another research study;
* Allergy to the components in the dietary supplement (inulin, fructooligosaccharide, blueberries, black currant, rice);
* History of drug or alcohol abuse;
* Use of antibiotics within the last 6 months;
* Use of prebiotics or flavonoid-containing dietary supplements within the last 30 days;
* Multiple food allergies or significant food preferences or restrictions that would interfere with diet adherence;
* Chronic use of over-the-counter medication which would interfere with study endpoints including NSAIDS, laxatives and antacids;
* Participating in or planning to begin a weight loss diet during the study period;
* Lifestyle or schedule incompatible with the study protocol;
* Other medical, psychiatric, or behavioral conditions that in the view of the principal investigator may present a safety hazard to the participant or interfere with study participation or the ability to follow the intervention protocol;
* Use of tobacco products.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Utah State University

OTHER

Sponsor Role collaborator

Pharmanex

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Lefevre, PhD

Role: PRINCIPAL_INVESTIGATOR

Utah State University

Locations

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Utah State University

Logan, Utah, United States

Site Status

Countries

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United States

Other Identifiers

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16-PHX-0003

Identifier Type: -

Identifier Source: org_study_id

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