Impact of Age and Geriatric Co-morbidities on Lymphocyte Phenotype in Patients 70 Years of Age and Older

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2021-11-30

Study Completion Date

2021-11-30

Brief Summary

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An individual's immune profile changes with age, and can sometimes be involved in the development of certain diseases such as infections or cancers, in a process called immunosenescence. Some data tend to show that there is a link between this immune profile and geriatric fragility (autonomy, difficulties with walking, memory, undernutrition, co-morbidities, depression). The aim of this study is to describe this profile, or immune phenotype, and to see if there is a link with the different aspects of geriatric assessment in patients without cancer or infection. In addition, these data will serve as a basis for comparison with the same analyses performed on breast cancer patients at the Centre Georges François Leclerc.

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Detailed Description

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Conditions

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Geriatrics Immunosenescence

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Seniors

70 years of age and over, inpatients or outpatients

Blood samples

Intervention Type BIOLOGICAL

during the routine blood test, collection of additional blood samples:

* 1 x 5 mL heparinized tube for plasma collection and storage
* 1 heparinized 5 mL tube for immunophenotyping
* 4 x 10 mL EDTA tubes for white blood cell (WBC) collection and cryopreservation

Data collection

Intervention Type OTHER

* clinical examination data
* test results to measure the degree of geriatric fatigability
* Frailty screening questionnaire for neoplasia patients (G8 score)

Interventions

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Blood samples

during the routine blood test, collection of additional blood samples:

* 1 x 5 mL heparinized tube for plasma collection and storage
* 1 heparinized 5 mL tube for immunophenotyping
* 4 x 10 mL EDTA tubes for white blood cell (WBC) collection and cryopreservation

Intervention Type BIOLOGICAL

Data collection

* clinical examination data
* test results to measure the degree of geriatric fatigability
* Frailty screening questionnaire for neoplasia patients (G8 score)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Person who has not opposed to inclusion in the study
* Male or female aged 70 and over admitted to the Champmaillot Geriatric Center on an inpatient or outpatient basis.

Exclusion Criteria

* Person not affiliated to national health insurance system
* Person subject to a measure of legal safeguard (curatorship, etc)
* Person with an acute infection
* Person with suspected cancer or active cancer
* Long-term immunosuppressive or corticosteroid therapy
* HIV and/or HBV and/or HCV positive serology

Minimum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No