Covid-19 Vaccine Response in Elderly Subjects

NCT ID: NCT04760704

Last Updated: 2025-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

264 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-18

Study Completion Date

2023-03-28

Brief Summary

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The objective of this research is to assess the amplitude and quality of the vaccine response against SARS-CoV-2, defined here by its characteristics established at 3 months, and its persistence over time, defined here at 9 months, in subjects residing in medical establishment for dependent elderly persons, compared to immunocompetent subjects aged 40 to 65 years (control subjects for vaccination over the same period).

Detailed Description

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Conditions

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Covid19 Vaccine

Keywords

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SARS-CoV-2 vaccination immunosenescence

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Experimental group

Persons aged 65 and over, residing in an institution for dependant elderly or in a long-term care unit

Specific antibody and cellular immune response after anti-SARS-CoV-2 vaccine administration

Intervention Type BIOLOGICAL

Specific T cells and specific antibodies assessment

control group

Health and medico-social professionals between 40 and 65 years of age

Specific antibody and cellular immune response after anti-SARS-CoV-2 vaccine administration

Intervention Type BIOLOGICAL

Specific T cells and specific antibodies assessment

Interventions

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Specific antibody and cellular immune response after anti-SARS-CoV-2 vaccine administration

Specific T cells and specific antibodies assessment

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

Target population.

* Elderly persons \> 65 years old residing in an institution for the elderly or in a long-term care unit for whom an anti-SARS-CoV-2 vaccination is indicated as recommended by French Health Authority (HAS)
* Male or female resident in an institution for the elderly or in a long-term care unit
* For whom consent has been obtained prior to any SARS-CoV-2 vaccination (or from the legal guardian/curator) by COMIRNATY®.
* Having consented to participate in the study, and willing to comply with all study procedures and its duration
* Socially insured patient

Control population

* Health and medico-social sector professionals aged between 40 and 65 years old for whom a COMIRNATY® anti-SARS-CoV-2 vaccination is indicated as recommended by the HAS.
* Male or female between 40 and 65 years of age included
* For whom consent has been obtained prior to any COMIRNATY® SARS-CoV-2 vaccination.
* Having consented to participate in the study, and willing to comply with all study procedures and its duration
* Socially insured subject

Exclusion Criteria

* Progressive infectious pathology
* Progressive neoplastic pathology (or remission of \< 5 years)
* Treatment with long-term corticosteroids or immunosuppressants
* Refuse of consent to vaccination or study
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Guillaume LEFEVRE, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

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CHU lille

Lille, , France

Site Status

Countries

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France

Other Identifiers

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2021-A00119-32

Identifier Type: OTHER

Identifier Source: secondary_id

2021_02

Identifier Type: -

Identifier Source: org_study_id