COVID-19 Serology and Immunosenescence

NCT ID: NCT04563650

Last Updated: 2024-04-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

98 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-18

Study Completion Date

2024-11-30

Brief Summary

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This study aims to determine how long COVID-19 neutralizing antibodies can be detected in an elderly institutionalized population presenting fragility factors.

This study also aims to stratify seroconversion by immunological profiles of the elderly patients residing in the EHPAD. This stratification requires the measurement of immunological marker levels already described in immunosenescence and also involved in the development of certain chronic infectious diseases more common in the elderly population. This analysis will enable the investigators to describe an immunological, clinical and biological profile representing a patient who has developed an immunity against COVID 19. It will also help the investigators to understand the different mechanisms leading to a reduced immune response after a potential administration of a vaccine. Finally, it will help describe the immune profiles of elderly residents who presented with non-severe forms of COVID-19.

Detailed Description

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Conditions

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Covid19 Geriatric Medicine Seroconversion Immunosenescence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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COVID-19 positive resident

Group Type EXPERIMENTAL

blood sample

Intervention Type BIOLOGICAL

Sample collection of 4 to 10 tubes of whole blood will be done according to centre Saint-Victor's protocol.

COVID-19 negative resident

Group Type ACTIVE_COMPARATOR

blood sample

Intervention Type BIOLOGICAL

Sample collection of 4 to 10 tubes of whole blood will be done according to centre Saint-Victor's protocol.

Interventions

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blood sample

Sample collection of 4 to 10 tubes of whole blood will be done according to centre Saint-Victor's protocol.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Residents of the EHPAD/USLD St Victor of the Amiens CHU who took part in the screening campaign (RT-PCR and serology) organized by the Amiens CHU
* residents who signed a consent form to participate in the study

Exclusion Criteria

* The patient or his legal representative refused to participate in the study
* Heavily sedated patients
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Amiens

Amiens, , France

Site Status

Countries

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France

Other Identifiers

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PI2020_843_0079

Identifier Type: -

Identifier Source: org_study_id

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