DNA-based Testing in BAL of Lung Transplant Recipients With Suspected Non-viral Lower Respiratory Tract Infection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

48 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-31

Study Completion Date

2016-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Lung transplantation (LTx) , DNA-based testing.

Performance of DNA-based testing of bacterial and fungal pathogens in comparison to standard testing.

Experimental intervention: DNA-based testing of BAL fluid.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Rapid Analysis of Infections by Spectrometry of Exhaled Breath

NCT03299608

Respiratory Tract Infections Hematologic Diseases

RECRUITING

Fast Identification of Pathogen in the Setting of Pneumonia Using Multiplex PCR

NCT01858974

Acute Lower Respiratory Tract Infection Pneumonia

COMPLETED

Evaluation of Tolsura When Used as Prophylaxis After Lung Transplantation

NCT04652050

Lung Transplant Infection

WITHDRAWN

Rapid Detection of Airway Pathogens for Lung Transplantation

NCT03933878

Lung Transplantation Respiratory Tract Infections Pulmonary Infection

COMPLETED

Molecular vs Conventional Microbiologic Diagnosis for Infections in Lung Transplantation

NCT05960383

Lung Transplant Infection Molecular Diagnostic Bacterial Infections +2 more

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Cohen's kappa of any pathogen isolation by DNA-based testing vs. standard cultures in comparison to the final diagnosis of non-viral lower respiratory tract infection.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Lower Respiratory Tract and Lung Infections

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Experimental Intervention: DNA-based testing of BAL fluid

DNA based testing needs 4.5 hours lab time in addition to standard testing

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* patients after lung transplantation (single, double or combined)
* suspicion of non-viral lower respiratory tract infection as defined by at least 2 out of
* new onset of malaise
* new or progressive pulmonary infiltrate
* hypoxemia (SpO2/SaO2 \<92% or need for oxygen)
* temperature of 38 o C or above within 7 days
* purulent (yellow or greenish) sputum
* CRP of 30 mg/l or above
* PCT of 0,5 µg/l or above