Evaluation of Tolsura When Used as Prophylaxis After Lung Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-01

Study Completion Date

2023-04-01

Brief Summary

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This is a single-center, observational study of Tolsura PK sampling in lung transplant recipients

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Detailed Description

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Patients who are receiving Tolsura as part of their clinical care will be asked to enroll and EMR data and excess biological samples will be collected

Conditions

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Lung Transplant Infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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lung transplants

Lung transplants on Tolsura for infection

Tolsura

Intervention Type DRUG

Patients fulfilling the inclusion criteria (see above) and placed on Tolsura for prophylaxis, and signed informed consent to participate in this study will be part of the study.

Interventions

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Tolsura

Patients fulfilling the inclusion criteria (see above) and placed on Tolsura for prophylaxis, and signed informed consent to participate in this study will be part of the study.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 18 years of age and older
* hospitalized at UPMC
* placed on Tolsura prophylactically by clinical team
* patients who have had or will have a lung transplant.

Exclusion Criteria

* redo lung transplant
* recipient with dual liver-lung transplant
* patients with previous history of SOT
* including other organ transplantation
* patients with known pre-transplant colonization with moulds resistant to azoles
* patients with intra-transplant positive cultures for moulds in either transplant recipient or his/her donor
* patients with a history of hypersensitivity reaction to an azole agent
* patients who are kept NPO (nothing by mouth, including meds)
* recipients or donor with HepC PCR positive

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No