Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy

NCT ID: NCT02912520

Last Updated: 2017-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-30

Study Completion Date

2017-04-23

Brief Summary

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Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and without antibiotic therapy in order to detect significant differences.

Detailed Description

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Conditions

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Immunoglobulin A

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with antibiotic therapy

Patients with antibiotic therapy for 2 weeks.

Anti-Bacterial Agents

Intervention Type DRUG

administration of any antibiotic substance(s) over the course of 2 weeks

Patients without antibiotic therapy

Patients without any antibiotic therapy in the last 3 months.

No interventions assigned to this group

Interventions

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Anti-Bacterial Agents

administration of any antibiotic substance(s) over the course of 2 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* endotracheal intubation
* antibiotic therapy for 2 weeks OR no antibiotic therapy for at least 3 months

Exclusion Criteria

* active infection
* pregnancy
* immunodeficiency
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical University of Vienna

OTHER

Sponsor Role lead

Responsible Party

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Oliver Robak

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Oliver Robak, MD

Role: PRINCIPAL_INVESTIGATOR

Medical University of Vienna

Locations

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Medical University of Vienna

Vienna, , Austria

Site Status

Countries

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Austria

References

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Hoogkamp-Korstanje JA, de Koning J, Heesemann J, Festen JJ, Houtman PM, van Oyen PL. Influence of antibiotics on IgA and IgG response and persistence of Yersinia enterocolitica in patients with Yersinia-associated spondylarthropathy. Infection. 1992 Mar-Apr;20(2):53-7. doi: 10.1007/BF01711062.

Reference Type BACKGROUND
PMID: 1582684 (View on PubMed)

Other Identifiers

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ORV001

Identifier Type: -

Identifier Source: org_study_id

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