HLA-G Immuno-Inhibitor Checkpoint Study in Patients With COVID-19 Infection: Molecular and Cellular Assessment

NCT ID: NCT04613297

Last Updated: 2022-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

91 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-19

Study Completion Date

2022-07-19

Brief Summary

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The aim of the research is to study the immune checkpoint linked to the HLA-G molecule in the dysregulation of the control of COVID-19 infection.

Detailed Description

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Single-center, prospective, open-ended, interventional study with minimal risks and constraints. Patients will be divided into 3 groups: patients not infected with COVID-19, patients infected with COVID-19 not hospitalized, patients infected with COVID-19 hospitalized.

Conditions

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Covid19

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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COVID-19 uninfected patients

Patient with negative PCR result

Group Type OTHER

Baseline blood sample

Intervention Type OTHER

Blood sample will be performed at the inclusion visit only

non-hospitalized COVID-19 infected patients

Patient with positive PCR result who does not require hospitalization for COVID-19

Group Type OTHER

Baseline blood sample

Intervention Type OTHER

Blood sample will be performed at the inclusion visit only

hospitalized COVID-19 infected patients

Patient with positive PCR who require hospitalization for COVID-19

Group Type OTHER

Baseline and during hospitalization blood samples

Intervention Type OTHER

Blood sample will be performed at the inclusion visit for all patient and for the hospitalized COVID-19 infected patients, extra-blood samples will be performed :

* at day 3
* day 5 and
* In case of aggravation
* At the discharge from hospital

Interventions

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Baseline and during hospitalization blood samples

Blood sample will be performed at the inclusion visit for all patient and for the hospitalized COVID-19 infected patients, extra-blood samples will be performed :

* at day 3
* day 5 and
* In case of aggravation
* At the discharge from hospital

Intervention Type OTHER

Baseline blood sample

Blood sample will be performed at the inclusion visit only

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient with possible or confirmed infection by COVID-19

Exclusion Criteria

* Patient without liberty or guardianship
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hopital Foch

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Olivier BRUGIERE, PhD

Role: PRINCIPAL_INVESTIGATOR

Hopital Foch

Locations

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Foch hospital

Suresnes, , France

Site Status

Countries

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France

Other Identifiers

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2020_0082

Identifier Type: -

Identifier Source: org_study_id

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