Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-06

Study Completion Date

2019-11-14

Brief Summary

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Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship. We suggest studying the interleaving between the endocannabinoidome-microbiome axis and host metabolism under the combined effect of a diet and physical activity. More specificly, we will study the link between the impact of the diet on the intestinal microbiome and the endocannabinoid reaction after intense exercise.

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Detailed Description

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Aims of the study are to compare the impacts of two short 7-day contrasted nutritional interventions (the Mediterranean diet (MED) and the Canadian diet (CAN)) on blood metabolites (endocannabinoids) after a maximal aerobic test. A 3 weeks washout between the two diets is planned. Gut microbiome at each test will also be evaluated.

Conditions

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Diet Habit Microbial Colonization Activity, Motor

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Mediterannen diet

The MED diet was abundant in fiber, micronutrients and plant-based proteins. The diet was rich in essential FA like monounsaturated fatty acids (MUFA) and n-3.

Group Type EXPERIMENTAL

3 maximal aerobic tests

Intervention Type OTHER

Maximal aerobic tests will be performed before diet intervention, after the first diet and after the second diet

Canadian diet

The NAM diet had a high content in saturated fatty acids (SFA) and simple sugar and was low in fiber.

Group Type EXPERIMENTAL

3 maximal aerobic tests

Intervention Type OTHER

Maximal aerobic tests will be performed before diet intervention, after the first diet and after the second diet

Interventions

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3 maximal aerobic tests

Maximal aerobic tests will be performed before diet intervention, after the first diet and after the second diet

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* women
* 20-30 years old
* healthy
* jogging \>1h/week and \>3h/week of physical activity
* bmi 18.5-25

Exclusion Criteria

* postmenopausal, pregnancy or lactation
* pathology or medication
* smoking
* more than 7 alcohol consumption/week
* food allergy, food intolerance or food aversion
* important weight change in the last 6 months
* antibiotics in the last 3 months
* night worker
* pathologies

Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes