Multidimensional Apathy in Psychiatric Pathologies.

NCT ID: NCT04757220

Last Updated: 2025-08-03

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 144 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-01-05
• Study Completion Date: 2027-03-01

Brief Summary

Apathy is defined by quantitative decrease in goal-directed activity in comparison to the person's previous level of functioning. Apathy is a transnosographic symptom, prevalent in many neurological and psychiatric pathologies (specifically in schizophrenia and depression), and almost half of patients suffer from it. It is an important source of burden, affecting both personal and occupational life. Despite its high prevalence and negative consequences, no pharmacological or non-pharmacological treatments exist, the underlying mechanisms of apathy being poorly understood. The main aim of the present study is to advance in our knowledge of cognitive and neural mechanisms of apathy by using a multidimensional model of apathy, distinguishing three forms: executive, emotional and auto-activation/initiative.

the investigators hypothesize, independently of the pathology (schizophrenia and depression), the existence of different cognitive deficits underlying each of the 3 subforms of apathy. Indeed, according to the predictions of Levy and Dubois' model (2006), executive disorders underlie the cognitive form of apathy. It may be related to lesions of the dorsolateral prefrontal cortex and the cognitive territory of the basal ganglia. Emotional apathy could be due to motivational disorder. Dysfunctions or lesions in the orbital and medial prefrontal cortex and limbic territories of the basal ganglia may underlie this. Finally, the initiative form, may be a mixed form, with both motivational and executive difficulties. Lesions or dysfunctions may affect both the cognitive and limbic territories of the basal ganglia or the anterior cingulate cortex.

Conditions

Apathy

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Patients with schizophrenia

• 5 subjective questionnaires
• 4 cognitive tasks with EEG recordings

Group Type: EXPERIMENTAL

Cognitive tasks with EEG recording

Intervention Type: OTHER

questionnaires and cognitives tasks

Patients with depression

• 5 subjective questionnaires
• 4 cognitive tasks with EEG recordings

Group Type: EXPERIMENTAL

Cognitive tasks with EEG recording

Intervention Type: OTHER

questionnaires and cognitives tasks

Healthy controls

• 5 subjective questionnaires
• 4 cognitive tasks with EEG recordings

Group Type: ACTIVE_COMPARATOR

Cognitive tasks with EEG recording

Intervention Type: OTHER

questionnaires and cognitives tasks

Interventions

Cognitive tasks with EEG recording

questionnaires and cognitives tasks

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• age between 18 and 60 years
• men or women volunteers, hospitalized or not
• subject affiliated to an health insurance
• subject having signed an informed consent

• presence of DSM-V TR criteria for schizophrenia (American Psychiatric Association, 1994)

• presence of DSM-V TR criteria for depression (American Psychiatric Association, 1994)

Exclusion Criteria

• a major or non stabilized somatic disorder
• medical history likely to affect cerebral anatomy or linked to an abnormality (neonatal distress, neurochirurgical intervention, neurological disorders, stroke attack)
• any disorders involved in the use of a psycho-active substance (as defined by the DSM-IV)
• sensory disabling impairments, and specifically visual acuity < 8
• general anaesthesia during the 3 months before the study
• pregnancy (declared by the subject)
• persons in an emergency situation
• persons deprived in any way of their liberty
• persons in period of exclusion in an other protocol

• use of psychotropic substance during the 3 weeks before the study

• use of benzodiazepines

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Strasbourg, France

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Service de Psychiatrie, Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Strasbourg, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Fabrice Berna, MD

Role: CONTACT

fabrice.berna@chru-strasbourg.fr

00333 ext. 88116132

Anne Bonnefond, PHD

Role: CONTACT

anne.bonnefond@unistra.fr

00333 ext. 88116132

Facility Contacts

Fabrice BERNA, MD

Role: primary

fabrice.berna@chru-strasbourg.fr

33.3.88.11.64.62

Other Identifiers

8062

Identifier Type: -

Identifier Source: org_study_id