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The Effect of Amputation on Spatial Visual Representation in Peripersonal Space

NCT ID: NCT00458757

Last Updated: 2017-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-11-30

Brief Summary

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In this study, we wish to find behavioral evidence for the question whether an amputation of the arm can lead to changes in visual perception or motor responses to objects in peripersonal space. We hypothesize that changes in the motor and somatosensory hand-related cortices following amputation might lead to changes in parietal hand-related areas. The consequence of these parietal changes should be reflected behaviorally in reduced perception/attention/responses to hand-related objects in the space ipsilateral to the amputation. We further hypothesize that the use of prosthetics may provide the necessary visual feedback to maintain an intact hand representation and therefore lead to lesser cortical reorganization in both visual and somatosensory cortical areas.

Detailed Description

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In a recent fMRI study (Makin TR. et al., J. Neurosci. 2007), we found extended cortical representation for a visual stimulus provided that it is presented close to the hand. It is therefore interesting to ask whether changes in the brain following limb amputation might induce changes in the amputees' perception of the body and consequently it's surrounding. In this study, we wish to find behavioral evidence for the question whether an amputation of the arm can lead to changes in visual perception or motor responses to objects in peripersonal space. We hypothesize that changes in the motor and somatosensory hand-related cortices following amputation might lead to changes in parietal hand-related areas. Consequently, we expect to find reduced perception/attention/responses to hand-related objects in the space ipsilateral to the amputation.

In this experiment we plan to employ a paradigm which is inspired by the affordance effect, originally introduced by Tucker and Elice (1998): we will present subjects with brief images of either manipulable or non manipulable objects in either the left or right visual field. The subjects will be required to determine whether the object contains a metal or not, by moving either their left or their right shoulder. We predict that while the control group of normal subjects would show a congruency effect (that is superior performance (faster and more accurate responses) when the responding shoulder is congruent with the position of the objects, the amputees will show spatial biases towards the non-amputated side. This effect should be more prominent for the manipulable objects.

Conditions

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Upper Limb Amputees

Keywords

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Amputees Affordance Peripersonal space Pseudo neglect Reaching Spatial visual

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Upper limb amputee, amputation above wrist.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hadassah Medical Organization

OTHER

Sponsor Role lead

Principal Investigators

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Isabella Schuartz, MD

Role: PRINCIPAL_INVESTIGATOR

Rehabilitation Dep. Hadassah Medical Hospital, Mount Scopus, Jerusalem

Locations

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Neurobiology Dep., Life Sciences Institute, Hebrew Uni.

Jerusalem, , Israel

Site Status

Countries

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Israel

Central Contacts

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Isabella Schuartz, MD

Role: CONTACT

Phone: 00 972 50 8573783

Email: [email protected]

References

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Makin TR, Holmes NP, Zohary E. Is that near my hand? Multisensory representation of peripersonal space in human intraparietal sulcus. J Neurosci. 2007 Jan 24;27(4):731-40. doi: 10.1523/JNEUROSCI.3653-06.2007.

Reference Type BACKGROUND
PMID: 17251412 (View on PubMed)

Tucker M, Ellis R. On the relations between seen objects and components of potential actions. J Exp Psychol Hum Percept Perform. 1998 Jun;24(3):830-46. doi: 10.1037//0096-1523.24.3.830.

Reference Type BACKGROUND
PMID: 9627419 (View on PubMed)

Other Identifiers

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090767-amputy-HMO-CTIL

Identifier Type: -

Identifier Source: org_study_id