Social Cognition in Huntington's Disease: Cognitive Study and Functional and Morphological Imaging

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2017-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Huntington's disease is a rare genetic neurodegenerative disease. It is accompanied by movement disorders, cognitive and behavioral. The social behavior of patients are changed, affecting interpersonal relationships. Patients with Huntington's disease are described as self-centered, lacking sympathy and empathy and mentally inflexible. These behavioral problems can be a major source of anxiety for patients and their families. These disorders also have a negative impact cognitive and motor symptoms as well as the functional abilities and the quality of life of patients and their entourage. Authors have suggested that these problems could be related inter alia to social cognition disorders. This concept refers to a set of skills and emotional and social experiences that regulate relations between individuals and can explain the behavior of individuals and groups. The objective is to evaluate disorders of social cognition, which may account for behavioral changes in Huntington's disease.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Functional Imaging of Social Cognition in Premanifest Huntington's Disease

NCT02551705

Huntington's Disease

UNKNOWN NA

Assessment of the Psychological, Cognitive and Social Resources of Applicants for Huntington's Disease and Presymptomatic Genetic Testing

NCT02134561

Presymptomatic Huntington Disease

COMPLETED NA

Evaluation of Three Tests to Assess Social Cognition in Huntington Disease

NCT07253038

Huntington Disease

NOT_YET_RECRUITING

Study of Huntington Patients in Connection With European Huntington's Disease Network (EHDN)

NCT01554033

Huntington Disease

UNKNOWN

Feasibility of a Video-oculography in Patients With Huntington's Disease VOG-HD Study

NCT02563418

Huntington Disease

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Huntington's Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

presymptomatic patient

patient with Unified Huntington's Disease Rating Scale (UHDRS) \< 5

Group Type OTHER

neuropsychological test

Intervention Type BEHAVIORAL

MRI

Intervention Type RADIATION

symptomatic patient

patient with Unified Huntington's Disease Rating Scale (UHDRS) \> 5

Group Type OTHER

neuropsychological test

Intervention Type BEHAVIORAL

MRI

Intervention Type RADIATION

controls

unaffected patient with Huntington's disease

Group Type OTHER

neuropsychological test

Intervention Type BEHAVIORAL

MRI

Intervention Type RADIATION

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

neuropsychological test

Intervention Type BEHAVIORAL

MRI

Intervention Type RADIATION

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

For all particpipants

* Patient gave its written consent
* between 20 and 70 years
* School level : at least 7 years
* native language: french

For presymptomatic patient

* Huntington's disease diagnosed with abnormal number of CAG repeats: 36 \< nucleotide expansion (CAG)
* Unified Huntington Disease Rating Scale moteur ≤ 5

For symptomatic patient

* Huntington's disease diagnosed with abnormal number of CAG repeats: 36 \< nucleotide expansion (CAG)
* Unified Huntington Disease Rating Scale moteur \> 5

Exclusion Criteria

* No national health insurance affiliation
* Being under guardianship
* Pregnant or lactating women
* Patient with involuntary movement hampering the realization of MRI

Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes