Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
NCT ID: NCT05707663
Last Updated: 2025-12-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
40 participants
OBSERVATIONAL
2023-04-17
2026-08-31
Brief Summary
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* Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)?
* Can reliable biomarkers for JoHD be found in brain structure and function?
Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.
Detailed Description
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In an effort to better understand the developmental aspects of this brain disease, the current study proposes to evaluate brain structure and function in children, adolescents, and young adults (ages 6-30) who have been diagnosed with JoHD. Brain structure will be evaluating using Magnetic Resonance Imaging (MRI) with quantitative measures of the entire brain, cerebral cortex, as well as white matter integrity via Diffusion Tensor Imaging. Brain function will be assessed by cognitive tests, behavioral assessment, and physical and neurologic evaluation. This study will test the hypothesis that comprehensive and longitudinal assessments of brain function and brain structure may produce reliable biomarkers of disease progression in JoHD.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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JoHD
Children adolescents and young adults ages 6-30 who have been clinically diagnosed with Juvenile-onset Huntington's Disease
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Aged 6-30
Exclusion Criteria
* History of head trauma, brain tumor, seizures or epilepsy unrelated to JoHD
* History of major surgery or serious chronic medical conditions other than JoHD
6 Years
30 Years
ALL
No
Sponsors
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Columbia University
OTHER
University of California, Davis
OTHER
The University of Texas Health Science Center, Houston
OTHER
Children's Hospital of Philadelphia
OTHER
George-Huntington-Institut GmbH
OTHER
UCL Queen Square Institute of Neurology
OTHER
University of Iowa
OTHER
Responsible Party
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Peggy C Nopoulos
Professor
Principal Investigators
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Peggy C Nopoulos, MD
Role: PRINCIPAL_INVESTIGATOR
University of Iowa
Locations
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University of California Davis
Sacramento, California, United States
University of Iowa Hospitals and Clinics, Department of Psychiatry
Iowa City, Iowa, United States
Columbia University Medical Center
New York, New York, United States
Children's Hospital of Philadelphia with the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
University of Texas Health Science Center at Houston
Houston, Texas, United States
Countries
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Central Contacts
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Facility Contacts
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Raj Tsutsui, BS
Role: primary
Keara Turkington, BA
Role: primary
Mia Parker
Role: primary
Shana Ward, BS
Role: primary
Isabelle Taylor, BS
Role: primary
Brittany Duncan, BS
Role: primary
References
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Nopoulos PC. Special Issue: Juvenile Onset Huntington's Disease. Brain Sci. 2020 Sep 20;10(9):652. doi: 10.3390/brainsci10090652.
Related Links
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Study site
Study site
Study site
Other Identifiers
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201109879
Identifier Type: -
Identifier Source: org_study_id