Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
NCT ID: NCT06241924
Last Updated: 2025-07-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2024-02-05
2027-02-05
Brief Summary
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The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.
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Detailed Description
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The local field potentials (LFPs) will be collected during the same motor task in :
i) patients with Parkinson's disease, using a high-resolution electroencephalogram (EEG) and the PERCEPT(TM) system (Medtronic) equipped with a "sensing" function for deep LFP recordings and in EEG-HR (for high resolution) for cortical recordings
ii) patients with focal drug-resistant epilepsy, during a pre-surgical assessment by stereo-electro-encephalography (SEEG). The SEEG allows the recording of both the cortex and the subcortical regions in a concomitant manner, and a direct correlation can be studied.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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Epilepsy
Stereo-electro-encephalography (SEEG)
Local field potentials (LFP) recording using sEEG
parkinson disease
High Resolution Electroencephalogram (EEG-HR)
Local field potentials (LFP) recording using EEG-HR
Interventions
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High Resolution Electroencephalogram (EEG-HR)
Local field potentials (LFP) recording using EEG-HR
Stereo-electro-encephalography (SEEG)
Local field potentials (LFP) recording using sEEG
Eligibility Criteria
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Inclusion Criteria
* Between 18 and 75 years of age
* With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
* Giving free, informed, written consent signed by the participant and the investigator Or
* With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
* With at least one electrode exploring the basal ganglia or the thalamus.
* Able to perform the simple motor task
* Affiliated or beneficiary of a social security scheme;
* Giving free, informed, written consent signed by the participant and the investigator
Exclusion Criteria
* Be subject to a legal protection measure or be placed under judicial protection;
* Being pregnant or breastfeeding
* Present a serious and/or decompensated somatic or psychiatric illness
18 Years
75 Years
ALL
No
Sponsors
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University Hospital, Bordeaux
OTHER
Responsible Party
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Principal Investigators
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Jérôme AUPY, Docteur
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Bordeaux
Locations
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CHU de Bordeaux
Bordeaux, , France
Countries
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Central Contacts
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Facility Contacts
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Jérôme Aupy
Role: primary
Other Identifiers
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CHUBX 2022/80
Identifier Type: -
Identifier Source: org_study_id
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