Role of Basal Ganglia and Thalamus in Perceptual Consciousness and Metacognition

NCT ID: NCT04461730

Last Updated: 2022-04-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2021-12-31

Study Completion Date

2025-11-30

Brief Summary

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The term perceptual awareness refers to subjective experience... or the phenomenology associated with the processing of a sensory stimulus. The term metacognition refers to our ability of introspection, knowledge and control of our own cognitive processes. The objective of this research is to establish the contribution of the basal ganglia and thalamus to the perceptual awareness and meta-cognition, using deep brain stimulation coupled with electroencephalography.

Detailed Description

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Conditions

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Parkinson Disease OCD Dystonia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Parkinson disease

deep brain stimulation

Intervention Type DEVICE

Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation

essential tremor

deep brain stimulation

Intervention Type DEVICE

Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation

dystonia

deep brain stimulation

Intervention Type DEVICE

Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation

OCD

deep brain stimulation

Intervention Type DEVICE

Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation

healthy volunteers

No interventions assigned to this group

Interventions

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deep brain stimulation

Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Major patient in need of brain stimulation therapy for motor disorders (Parkinson's disease, tremor, dystonia) or psychiatric disorders (OCD).
* Outpatient or inpatient follow-up
* Fluent in French and able to understand the study procedures
* informed consent
* Patient affiliated to social security
* Written agreement to participate in the patient's study
* Intellectual abilities compatible with the performance of cognitive or motor tasks

Exclusion Criteria

* Persons referred to in Articles L1121-5 to L1121-8 of the CSP (pregnant women, parturient women, mothers, etc.) who is breastfeeding, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure
* Patients in whom transient cessation of stimulation is not tolerated
* Subject in period of exclusion from another study
* Subject cannot be contacted in case of emergency
* Subject under administrative or judicial supervision
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ELENA MORO

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Grenoble

Other Identifiers

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2019-A02328-49

Identifier Type: OTHER

Identifier Source: secondary_id

38RC19.271

Identifier Type: -

Identifier Source: org_study_id

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