Periodic Limb Movement and Genetic Generalized Epilepsy
NCT ID: NCT03587506
Last Updated: 2018-07-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2015-09-03
2016-12-31
Brief Summary
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Detailed Description
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Periodic limb movement index and frequency were compared among the patients' groups and were correlated with different clinical characteristics.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients: group
Group I (n=10) included patients who did not develop any major or minor seizure during the follow-up period and their follow up EEG was free of any epileptiform discharge
No interventions assigned to this group
Patients: group II
Group II (n=11) included patients who developed only minor seizures and their follow up EEG showed epileptiform discharge
No interventions assigned to this group
Patients: group III
Group III (n=9) were patients who developed one or more major seizures during the follow-up period whatever their EEG findings.
No interventions assigned to this group
Controls
healthy volunteers (n=30) who were not related to the patients and had no family history of epilepsy.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* did not previously receive AEDs.
* The clinical seizures were either eyewitnessed by physicians or video-recorded to ensure they were true epileptic seizures.
* At least two unprovoked seizures occurring \>24 hours apart
Exclusion Criteria
* Patients with seizures due to toxic or metabolic causes (including glucose disturbance, uremia, and electrolytes disturbance), infections, or structural causes (such as neoplasms)
* Patients using hypnotic drugs
9 Years
29 Years
ALL
Yes
Sponsors
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University of Alexandria
OTHER
Responsible Party
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Eman Hamdy
Assistant lecturer of Neurology
References
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Bazil CW. Sleep and Epilepsy. Semin Neurol. 2017 Aug;37(4):407-412. doi: 10.1055/s-0037-1604352. Epub 2017 Aug 24. No abstract available.
Malow BA, Fromes GA, Aldrich MS. Usefulness of polysomnography in epilepsy patients. Neurology. 1997 May;48(5):1389-94. doi: 10.1212/wnl.48.5.1389.
Yazdi Z, Sadeghniiat-Haghighi K, Naimian S, Zohal MA, Ghaniri M. Prevalence of Sleep Disorders and their Effects on Sleep Quality in Epileptic Patients. Basic Clin Neurosci. 2013 Winter;4(1):36-41.
Vetrugno R, D'Angelo R, Montagna P. Periodic limb movements in sleep and periodic limb movement disorder. Neurol Sci. 2007 Jan;28 Suppl 1:S9-S14. doi: 10.1007/s10072-007-0733-0. No abstract available.
Karadeniz D, Ondze B, Besset A, Billiard M. EEG arousals and awakenings in relation with periodic leg movements during sleep. J Sleep Res. 2000 Sep;9(3):273-7. doi: 10.1046/j.1365-2869.2000.00202.x.
Parrino L, Ferri R, Bruni O, Terzano MG. Cyclic alternating pattern (CAP): the marker of sleep instability. Sleep Med Rev. 2012 Feb;16(1):27-45. doi: 10.1016/j.smrv.2011.02.003. Epub 2011 May 26.
Allena M, Campus C, Morrone E, De Carli F, Garbarino S, Manfredi C, Sebastiano DR, Ferrillo F. Periodic limb movements both in non-REM and REM sleep: relationships between cerebral and autonomic activities. Clin Neurophysiol. 2009 Jul;120(7):1282-90. doi: 10.1016/j.clinph.2009.04.021. Epub 2009 Jun 7.
Berg AT, Millichap JJ. The 2010 revised classification of seizures and epilepsy. Continuum (Minneap Minn). 2013 Jun;19(3 Epilepsy):571-97. doi: 10.1212/01.CON.0000431377.44312.9e.
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshe SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475-82. doi: 10.1111/epi.12550. Epub 2014 Apr 14.
Jagannath A, Peirson SN, Foster RG. Sleep and circadian rhythm disruption in neuropsychiatric illness. Curr Opin Neurobiol. 2013 Oct;23(5):888-94. doi: 10.1016/j.conb.2013.03.008. Epub 2013 Apr 23.
Flink R, Pedersen B, Guekht AB, Malmgren K, Michelucci R, Neville B, Pinto F, Stephani U, Ozkara C; Commission of European Affairs of the International League Against Epilepsy: Subcommission on European Guidelines. Guidelines for the use of EEG methodology in the diagnosis of epilepsy. International League Against Epilepsy: commission report. Commission on European Affairs: Subcommission on European Guidelines. Acta Neurol Scand. 2002 Jul;106(1):1-7. doi: 10.1034/j.1600-0404.2002.01361.x.
Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Guerreiro C, Kalviainen R, Mattson R, French JA, Perucca E, Tomson T; ILAE Subcommission on AED Guidelines. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2013 Mar;54(3):551-63. doi: 10.1111/epi.12074. Epub 2013 Jan 25.
Khatami R, Zutter D, Siegel A, Mathis J, Donati F, Bassetti CL. Sleep-wake habits and disorders in a series of 100 adult epilepsy patients--a prospective study. Seizure. 2006 Jul;15(5):299-306. doi: 10.1016/j.seizure.2006.02.018. Epub 2006 Mar 20.
Parrino L, Boselli M, Buccino GP, Spaggiari MC, Di Giovanni G, Terzano MG. The cyclic alternating pattern plays a gate-control on periodic limb movements during non-rapid eye movement sleep. J Clin Neurophysiol. 1996 Jul;13(4):314-23. doi: 10.1097/00004691-199607000-00005.
Parrino L, Smerieri A, Spaggiari MC, Terzano MG. Cyclic alternating pattern (CAP) and epilepsy during sleep: how a physiological rhythm modulates a pathological event. Clin Neurophysiol. 2000 Sep;111 Suppl 2:S39-46. doi: 10.1016/s1388-2457(00)00400-4.
Other Identifiers
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Alexandria Faculty of Medicine
Identifier Type: -
Identifier Source: org_study_id
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