Proprioception and Sensorimotor Control in Hereditary Sensory and Autonomic Neuropathy

NCT ID: NCT02876939

Last Updated: 2020-09-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-11-30
• Study Completion Date: 2019-07-25

Brief Summary

This project comprises three sets of physiological studies - testing eight specific hypotheses - that will contribute new knowledge on proprioception and motor control in a genetic disorder that affects specific components of the sensory nervous system.

I: To investigate the neurophysiological basis for disturbed motor control in Hereditary sensory and autonomic neuropathy (HSAN) III II: To investigate the effects of enhancing cutaneous feedback on motor control in HSAN III III: To investigate the cortical representation of proprioceptive inputs in HSAN III

Detailed Description

HSAN III patients (n=15) and healthy control subjects (n=15) will lay supine on an MRI bed and a tungsten microelectrode inserted percutaneously into a muscle or cutaneous fascicle of the right common peroneal nerve at the fibular head, according to standard techniques employed by Prof Macefield. Neural activity will be acquired, RMS-processed (200 ms) and analysed on computer. The subject's head will be tightly enclosed in a standard clinical 32-channel SENSE head coil and headphones will be provided to minimize noise and to allow communication with the subject. The subject will be placed in the bore of a 3T whole-body scanner for 60-90 minutes.

Conditions

Atunomic Neuropathy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

HSAN III

Group Type: EXPERIMENTAL

kinesiology tape around the hip, knee and ankle joints

Intervention Type: OTHER

We will also demonstrate that taping the skin increases the central representation of cutaneous afferent input in HSAN III.

No kinesiology tape around the hip, knee and ankle joints

Intervention Type: OTHER

Investigators will demonstrate that taping the skin increases the central representation of cutaneous afferent input in HSAN III.

Control Subjects

Group Type: ACTIVE_COMPARATOR

kinesiology tape around the hip, knee and ankle joints

Intervention Type: OTHER

We will also demonstrate that taping the skin increases the central representation of cutaneous afferent input in HSAN III.

No kinesiology tape around the hip, knee and ankle joints

Intervention Type: OTHER

Investigators will demonstrate that taping the skin increases the central representation of cutaneous afferent input in HSAN III.

Interventions

kinesiology tape around the hip, knee and ankle joints

We will also demonstrate that taping the skin increases the central representation of cutaneous afferent input in HSAN III.

Intervention Type: OTHER

No kinesiology tape around the hip, knee and ankle joints

Investigators will demonstrate that taping the skin increases the central representation of cutaneous afferent input in HSAN III.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Confirmed genetic diagnosis of HSAN III will be recruited from the Dysautonomia Center at NYU

Exclusion Criteria

• homeless
• active drug or alcohol dependence
• evidence of neurological disorder or diabetes
• exposure to neurotoxic drugs that in the investigator's opinion may compromise results
• Pregnant women

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

NYU Langone Health

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Horacio Kaufmann, MD

Role: PRINCIPAL_INVESTIGATOR

New York University Medical School

Locations

New York University School of Medicine

New York, New York, United States

Countries

United States

Other Identifiers

16-00530

Identifier Type: -

Identifier Source: org_study_id