Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-04-03

Study Completion Date

2023-12-31

Brief Summary

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Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

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Detailed Description

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This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Conditions

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Parkinson Cerebellar Tumor Rest Tremor Diagnoses Disease Movement; Abnormal, Involuntary

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Tremor of rest

Patient with a diagnosis of Parkinson's disease and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

EMG in wrist flexor-pronators and extensor-supinators

Intervention Type DIAGNOSTIC_TEST

The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Cerebellar tremor

Patient with a diagnosis of cerebellar tremor and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

EMG in wrist flexor-pronators and extensor-supinators

Intervention Type DIAGNOSTIC_TEST

The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Interventions

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EMG in wrist flexor-pronators and extensor-supinators

The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories;
* diagnosis of Parkinson's disease or cerebellar tremor.

Exclusion Criteria

* Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings;
* Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings;
* Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings;
* Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.

Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No