The Role of GABA-mediated Inhibition in Multisensory Temporal Processing & Postural Control in Older Adults
NCT ID: NCT03328455
Last Updated: 2024-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
50 participants
INTERVENTIONAL
2025-12-01
2031-11-30
Brief Summary
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Detailed Description
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Stimulus presentation. Visual and auditory stimuli will be generated using MATLAB and the psychophysics toolbox. Visual and auditory stimuli will be delivered via Display++ system and an AudioFile stimulus processor, respectively (Cambridge Research Systems). The use of these two devices allows for precise control of stimulus timing.
Inhibitory control training. Participants will be trained with tasks that involve both response withholding and rule switching. For example, participants will be asked to sort polygons based on features (e.g., shape or color) and will be asked to either provide or withhold sorting responses when presented with different cues. Rule-switching is introduced when participants must inhibit the "rule" used in the previous trial set and change the focus of their attention to a new sorting and/or inhibitory rule.
Knowledge-based training. This condition serves as the control. Participants will be presented with questions from different categories such as vocabulary, science, or geography and asked to select the correct answer from 4 alternatives within a certain time limit.
In both training conditions, task difficulty will progressively increase over the course of training based on participants' abilities. Pre- and post-training assessment of multisensory temporal processing abilities, postural stability and gait performance, brain GABA concentration, and resting-state based network segregation will be conducted.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Inhibitory control training
In the inhibitory control training condition, participants will be trained with tasks that involve both response withholding and rule switching. For example, participants will sort polygons based on features (e.g., shape or color) and will be asked to either provide or withhold sorting responses when presented with different cues. Rule-switching is introduced when participants must inhibit the "rule" used in the previous trial set and change the focus of their attention to a new sorting and/or inhibitory rule. Task difficulty will progressively increase over the course of training based on participants' abilities.
Inhibitory control training
Cognitive training is inhibitory task-related.
knowledge-based training
The knowledge-based training condition serves as the control, in which participants will be presented with questions from different categories such as vocabulary, science, or geography and asked to select the correct answer from 4 alternatives within a certain time limit. Task difficulty will progressively increase over the course of training based on participants' abilities.
Knowledge-based training
Training is not inhibitory task-related.
Interventions
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Inhibitory control training
Cognitive training is inhibitory task-related.
Knowledge-based training
Training is not inhibitory task-related.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* History of head injury with loss of consciousness, brain surgery, or psychiatric disorders
* Early dementia or cognitive impairment
* Serious vision problems (including best-corrected binocular visual acuity worse than 20/25)
* Uncorrected hearing problems (pure tone threshold \> 40 dB for 1000-2000 Hz)
20 Years
80 Years
ALL
Yes
Sponsors
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University of Nevada, Reno
OTHER
Responsible Party
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Fang Jiang
Associate professor
Principal Investigators
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Fang Jiang, Ph.D
Role: PRINCIPAL_INVESTIGATOR
University of Nevada, Reno
Countries
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Central Contacts
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Other Identifiers
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1086690
Identifier Type: -
Identifier Source: org_study_id