Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

NCT ID: NCT00664300

Last Updated: 2011-01-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-08-31
• Study Completion Date: 2009-10-31

Brief Summary

Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour…).

This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour.

We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

Detailed Description

20 patients with Gilles de la Tourette's syndrome compared to 20 healthy paired volunteers.

Study progress (patients):

Inclusion visit :

Psychiatric evaluation Psychological evaluation

Ophthalmic visit

Protocol :

Facial expression recognition test Lexical decision test

Study progress (healthy volunteers):

Psychiatric evaluation Ophthalmic visit Facial expression recognition test Lexical decision test

Conditions

Gilles de la Tourette's Syndrome

Study Groups

2

One group with Gilles de la Tourette's Syndrome One group with healthy paired volunteers

Facial expression recognition of emotion

Intervention Type: BEHAVIORAL

Facial expression recognition test Lexical decision test

Interventions

Facial expression recognition of emotion

Facial expression recognition test Lexical decision test

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Age : >18 years
• Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV
• Stability of treatment >1 month
• Mini Mental State > 26
• Affiliation to social security
• Agreement of patients

Exclusion Criteria

• Patients with cognitive disorders, dementia, mental retardation…
• Patients with serious neurological pathologies
• Patients with a vision contrast altered.
• Patients who do not understand the words associated with an emotion
• Pregnant women
• Person who participate to an other study

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Clermont-Ferrand

OTHER

Sponsor Role: lead

Responsible Party

CHU Clermont-Ferrand

Principal Investigators

Isabelle Jalenques, PUPH

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Clermont-Ferrand

Locations

CHU

Clermont-Ferrand, , France

Countries

France

Other Identifiers

RBHP 2007 Jalenques

Identifier Type: -

Identifier Source: secondary_id

CHU-0032

Identifier Type: -

Identifier Source: org_study_id