Objective Characterizatoion of Repetitive Behaviors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-28

Study Completion Date

2027-12-27

Brief Summary

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Introduction:

Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in obsessive-compulsive-disorder, OCD) and tics (found in Gilles de la Tourette syndrome, GTS). For some patients, it is sometime difficult to distinguish the nature of the repetitive behaviors presented, however this distinction is crucial in order to chose the appropriate treatment.

Aim:

In our study, the investigators will try to define electrophysiological and accelerometric marker of both OCD and tics to allow objective distinction between both tics and compulsions.

Method:

Subjects: Both OCD and GTS patients will be recruited, 25 patients in each group.

Protocol: our study protocol will involve two step: a step in laboratory, another step at patient home.

* first step: both patients group will be recorded through a high density EEG and a portative EEG while doing a task of symptom provocation. Then they will get an anatomical MRI for source recontruction. Finally, the patients will have to mimic their symptom while wearing an accelerometer (a smartwatch).
* second step: both patient groups will be recorded at home through a portative EEG while tagging their symptom through a smartwatch (also used for accelerometry). After the recording, the patients will keep the smartwatch for 2 weeks, still tagging their sympoms (compulsions or tics).

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Detailed Description

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Conditions

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OCD Tic Disorders Gilles De La Tourette Syndrome

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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GTS group

This arm will be studied to get some electrophysiological marker of tics. The patients will be their own control (periods with symptoms vs. free symptoms periods).

Group Type EXPERIMENTAL

EEG

Intervention Type DEVICE

Recording, from the scalp, the electrophysiological activity of the brain.

MRI

Intervention Type DEVICE

Get the anatomical shape of the brain.

OCD group

This arm will be studied to get some electrophysiological marker of compulsions. The patients will be their own control (periods with symptoms vs. free symptoms periods).

Group Type EXPERIMENTAL

EEG

Intervention Type DEVICE

Recording, from the scalp, the electrophysiological activity of the brain.

MRI

Intervention Type DEVICE

Get the anatomical shape of the brain.

Interventions

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EEG

Recording, from the scalp, the electrophysiological activity of the brain.

Intervention Type DEVICE

MRI

Get the anatomical shape of the brain.

Intervention Type DEVICE

Other Intervention Names

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Electroencephalogram magnetic resonance imaging

Eligibility Criteria

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Inclusion Criteria

* To be more of 15 years old or less than 65 years old
* To suffer from OCD and/or GTS (depressive, anxious and attention deficit hyperactivity disorder (ADHD) comorbidities are accepted)
* To be registered to the french social security (or something equivalent)
* To give written consent to participate to the research
* To have contraception for women participants (or to not have any sexual activity)

* Patients with any other neurological disorder than GTS
* Patients who are not able to take decisions for themselves
* Pregnant women
* Patients not allowed to get MRI due to contraindication
* Patients not speaking french

Minimum Eligible Age

15 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No