Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome
NCT ID: NCT04179435
Last Updated: 2019-11-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
132 participants
INTERVENTIONAL
2019-12-31
2023-12-31
Brief Summary
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Detailed Description
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Aim 1: To evaluate the maturation of cognitive functions in adolescents with TS compared to typically developing adolescents.
To achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) reward sensitivity and habit formation; (ii) cognitive impulsivity and action control and (iii) self-agency.
Aim 2: To identify neuronal correlates of cognitive function and brain development in health and disease. To achieve this aim, we will use a combined behavioural (as described in Aim 1), (i) neuroimaging and (ii) TMS approaches.
Aim 3: To predict clinical outcome . In this part of the project we aim to identify behavioural, imaging or neurophysiological markers of clinical outcome in patients with TS.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Tourette syndrome
Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures
Behavioral testing on cognitive computerized tasks
Testing on cognitive computerized tasks
brain MRI
Brain MRI scans
TMS
Measure of the cortical inhibitory capacity using TMS measures
Controls
Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures
Behavioral testing on cognitive computerized tasks
Testing on cognitive computerized tasks
brain MRI
Brain MRI scans
TMS
Measure of the cortical inhibitory capacity using TMS measures
Interventions
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Behavioral testing on cognitive computerized tasks
Testing on cognitive computerized tasks
brain MRI
Brain MRI scans
TMS
Measure of the cortical inhibitory capacity using TMS measures
Eligibility Criteria
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Inclusion Criteria
* Ages 13 - 18
* Acceptance to perform the Brain MRI
* Acceptance to perform the cognitive testing
* Acceptance to perform the TMS measures
Exclusion Criteria
* Incompatibility with MRI procedure (metal body implants, pregnancy)
13 Years
18 Years
ALL
Yes
Sponsors
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Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
Responsible Party
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Principal Investigators
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Worbe Yulia, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Institut National de la Santé Et de la Recherche Médicale, France
Central Contacts
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References
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Atkinson-Clement C, Duflot M, Lastennet E, Patsalides L, Wasserman E, Sartoris TM, Tarrano C, Rosso C, Burbaud P, Deniau E, Czernecki V, Roze E, Hartmann A, Worbe Y. How does Tourette syndrome impact adolescents' daily living? A text mining study. Eur Child Adolesc Psychiatry. 2023 Dec;32(12):2623-2635. doi: 10.1007/s00787-022-02116-1. Epub 2022 Dec 2.
Other Identifiers
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2019-A00992-55
Identifier Type: REGISTRY
Identifier Source: secondary_id
C19-11
Identifier Type: -
Identifier Source: org_study_id
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