Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
150 participants
INTERVENTIONAL
2015-10-31
2019-12-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Preterm Inhibition
In children born very preterm:
Inhibition training, Saliva collection, Brain Magnetic Resonance Imaging, Cognitive testing
Inhibition training
Inhibition training on a tactile tablet for a month (20 sessions of 15 min)
Saliva collection
Collection of a saliva sample for genotyping
Brain Magnetic Resonance Imaging
Structural and functional MRI
Cognitive testing
Battery of cognitive and academic tasks on executive functions
Full-term Inhibition
In children born full-term:
Inhibition training, Saliva collection, Brain Magnetic Resonance Imaging, Cognitive testing
Inhibition training
Inhibition training on a tactile tablet for a month (20 sessions of 15 min)
Saliva collection
Collection of a saliva sample for genotyping
Brain Magnetic Resonance Imaging
Structural and functional MRI
Cognitive testing
Battery of cognitive and academic tasks on executive functions
Full-term Working memory
In children born full-term:
Working memory training, Saliva collection, Brain Magnetic Resonance Imaging, Cognitive testing
Working memory training
Working memory training on a tactile tablet for a month (20 sessions of 15 min)
Saliva collection
Collection of a saliva sample for genotyping
Brain Magnetic Resonance Imaging
Structural and functional MRI
Cognitive testing
Battery of cognitive and academic tasks on executive functions
Full-term Mindfulness
In children born full-term:
Mindfulness training, Saliva collection, Brain Magnetic Resonance Imaging, Cognitive testing
Mindfulness training
Mindfulness training on a tactile tablet for a month (20 sessions of 15 min)
Saliva collection
Collection of a saliva sample for genotyping
Brain Magnetic Resonance Imaging
Structural and functional MRI
Cognitive testing
Battery of cognitive and academic tasks on executive functions
Full-term Active control
In children born full-term:
Active control training, Saliva collection, Brain Magnetic Resonance Imaging, Cognitive testing
Active control training
Active control training on a tactile tablet for a month (20 sessions of 15 min)
Saliva collection
Collection of a saliva sample for genotyping
Brain Magnetic Resonance Imaging
Structural and functional MRI
Cognitive testing
Battery of cognitive and academic tasks on executive functions
Interventions
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Inhibition training
Inhibition training on a tactile tablet for a month (20 sessions of 15 min)
Working memory training
Working memory training on a tactile tablet for a month (20 sessions of 15 min)
Mindfulness training
Mindfulness training on a tactile tablet for a month (20 sessions of 15 min)
Active control training
Active control training on a tactile tablet for a month (20 sessions of 15 min)
Saliva collection
Collection of a saliva sample for genotyping
Brain Magnetic Resonance Imaging
Structural and functional MRI
Cognitive testing
Battery of cognitive and academic tasks on executive functions
Eligibility Criteria
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Inclusion Criteria
* Aged 9-10 years at inclusion
* French school curriculum (since 1st grade)
* Fully informed through the dedicated booklet
* Both parents gave their written consent
* Normal medical, neurological and brain imaging assessment
Inclusion criterion for non preterm children only:
\- Full term pregnancy with no abnormal event (\>= 37 weeks of amenorrhea)
Inclusion criterion for preterm children only:
\- Delivery before 33 weeks of amenorrhea
Exclusion Criteria
* Monozygotic twins
* Restrictions to a Magnetic Resonance brain imaging exam: claustrophobia, metallic elements (cardiac implants, cochlear implants, metallic elements in the brain or the eyes and being close to the nervous system, metallic prothesis, braces), restless participants.
* Sudden cognitive impairments due to a stroke, head injury associated with loss of consciousness for more than one hour or encephalitis.
* Chronic neurological, psychiatric, infectious or liver condition, endocrine disruption.
* Past or current medical condition: cancer, diabetes, chronic lung condition, cardiac, metabolic, hematological, endocrine or immunological disorder.
* Medication assumed to interfere with brain imaging measures (psychotropics, hypnotics, anxiolytics, neuroleptics, benzodiazepine, steroidal anti-inflammatory, anti-epileptics, painkillers, muscle relaxants).
* Left-sided handedness
* Colour blindness or non-corrected visual disturbances
* Diagnosed developmental disorders
* Diagnosed cerebral palsy
* Diagnosed Fine motor disturbances
* Parents not affiliated to the Social Security
* Parents not able to join at each time of the study
9 Years
10 Years
ALL
Yes
Sponsors
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National Research Agency, France
OTHER
University Hospital, Caen
OTHER
Responsible Party
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Principal Investigators
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Olivier Houdé, Professor
Role: PRINCIPAL_INVESTIGATOR
University of Paris 5 - Rene Descartes
Locations
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GIP Cyceron
Caen, , France
Countries
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Central Contacts
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Facility Contacts
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Olivier Houdé, Professor
Role: primary
Grégoire Borst, Professor
Role: backup
Other Identifiers
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15-045
Identifier Type: OTHER
Identifier Source: secondary_id
2015-A00383-46
Identifier Type: -
Identifier Source: org_study_id