Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism

NCT ID: NCT01770548

Last Updated: 2017-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

497 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2014-06-30

Brief Summary

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Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism

Detailed Description

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Analysis about 50 genes in glutamate synapse

Conditions

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Autism

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Study Groups

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Autism

Analysis of the glutamate synapse in autism

Group Type EXPERIMENTAL

analysis of the glutamate synapse in autism

Intervention Type GENETIC

Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism

DNA collection

Intervention Type GENETIC

DNA collection

Auditory evoked potentials

Intervention Type OTHER

auditory evoked potentials

Relative

Analysis of the glutamate synapse in autism

Group Type OTHER

analysis of the glutamate synapse in autism

Intervention Type GENETIC

Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism

DNA collection

Intervention Type GENETIC

DNA collection

Auditory evoked potentials

Intervention Type OTHER

auditory evoked potentials

Major control

DNA collection

Group Type OTHER

analysis of the glutamate synapse in autism

Intervention Type GENETIC

Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism

DNA collection

Intervention Type GENETIC

DNA collection

Auditory evoked potentials

Intervention Type OTHER

auditory evoked potentials

Minor control

auditory evoked potentials

Group Type OTHER

Auditory evoked potentials

Intervention Type OTHER

auditory evoked potentials

Interventions

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analysis of the glutamate synapse in autism

Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism

Intervention Type GENETIC

DNA collection

DNA collection

Intervention Type GENETIC

Auditory evoked potentials

auditory evoked potentials

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* have a Pervasive Developmental Disorder

Exclusion Criteria

* N/A
Minimum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Tours

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Frédérique BONNET-BRILHAULT, MD PHD

Role: STUDY_DIRECTOR

University François Rabelais of TOURS

Locations

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CHRU - Centre de Ressources Autisme (CRA)

Brest, , France

Site Status

CHS du ROUVRAY

Rouen, , France

Site Status

Chru - Cic

Tours, , France

Site Status

CHRU - Pédopsychiatrie

Tours, , France

Site Status

Countries

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France

References

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Bonnet-Brilhault F, Alirol S, Blanc R, Bazaud S, Marouillat S, Thepault RA, Andres CR, Lemonnier E, Barthelemy C, Raynaud M, Toutain A, Gomot M, Laumonnier F. GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explorations distinguish autism from intellectual disability. Mol Psychiatry. 2016 Mar;21(3):411-8. doi: 10.1038/mp.2015.75. Epub 2015 Jun 9.

Reference Type RESULT
PMID: 26055424 (View on PubMed)

Other Identifiers

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2008-A01162-53

Identifier Type: OTHER

Identifier Source: secondary_id

AORT08-FBB/NMDA-Autism

Identifier Type: -

Identifier Source: org_study_id

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