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Functional MRI of Cognitive Control in Autism

NCT ID: NCT00463164

Last Updated: 2007-04-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-12-31

Brief Summary

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This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. We hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. Specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. We are conducting three functional Magnetic Resonance Imaging (fMRI) studies to address these hypotheses.

Detailed Description

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Conditions

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Autism

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged 6 - 12 years at inclusion


* DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview


* No DSM-IV (APA, 1994) diagnosis, according to DISC interview
* No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
* IQ \> 70

Exclusion Criteria

* Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
* Presence of metal objects in or around the body (pacemaker, dental braces)
* History of or present neurological disorder
Minimum Eligible Age

6 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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UMC Utrecht

OTHER

Sponsor Role lead

Principal Investigators

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Sarah Durston, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht

Herman van Engeland, M.D. Ph.D.

Role: STUDY_CHAIR

Rudolf Magnust Institute of Neuroscience, UMC Utrecht

Locations

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Dept. of Child and Adolescent Psychiatry, UMC Utrecht

Utrecht, , Netherlands

Site Status

Countries

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Netherlands

Central Contacts

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Sarah Durston, Ph.D.

Role: CONTACT

[email protected]
+31 30 250 8161

Related Links

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http://www.niche-lab.nl

Lab homepage with info for subjects (in Dutch)

Other Identifiers

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06-179

Identifier Type: -

Identifier Source: org_study_id