Study Results
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Basic Information
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COMPLETED
NA
61 participants
INTERVENTIONAL
2021-03-01
2022-03-17
Brief Summary
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Detailed Description
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In this study the investigators will perform an 8-week dietary intervention with SAA restriction to characterise the effects on several parameters related to metabolic health including body weight, body composition, energy expenditure, lipid profile and gene expression profiles in adipose tissue. The aim is to translate findings from previous animal experiments to humans
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Low SAA diet
Dietary intervention
Low SAA diet
Diet with low content of methionine and cysteine
High SAA diet
Dietary intervention
High SAA diet
Diet with high content of methionine and cysteine
Interventions
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Low SAA diet
Diet with low content of methionine and cysteine
High SAA diet
Diet with high content of methionine and cysteine
Eligibility Criteria
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Inclusion Criteria
* Waist circumference \> 80 cm for women and \> 94 cm for men
Exclusion Criteria
* Presence of chronic disease
* Established co-morbidities
* Already on a vegan diet or have been the last month
* Pregnancy
* Breastfeeding the last 3 months
* Unstable body weight the last 3 months
* High intensity training \> 3 times weekly
18 Years
45 Years
ALL
Yes
Sponsors
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Charles University, Czech Republic
OTHER
Maastricht University
OTHER
University of Oxford
OTHER
University of Oslo
OTHER
Responsible Party
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Kathrine Vinknes
Researcher
Principal Investigators
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Kjetil Dr Retterstøl, Prof. dr med
Role: STUDY_DIRECTOR
University of Oslo
Locations
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Centre for Clinical Nutrition, University of Oslo/Oslo University Hospital
Oslo, , Norway
Countries
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References
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Olsen T, Vinknes KJ, Barvikova K, Stolt E, Lee-Odegard S, Troensegaard H, Johannessen H, Elshorbagy A, Sokolova J, Krijt J, Krizkova M, Ditroi T, Nagy P, Ovrebo B, Refsum H, Thoresen M, Retterstol K, Kozich V. Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass and adipose tissue gene expression. Redox Biol. 2024 Jul;73:103192. doi: 10.1016/j.redox.2024.103192. Epub 2024 May 17.
Olsen T, Stolt E, Ovrebo B, Elshorbagy A, Tore EC, Lee-Odegard S, Troensegaard H, Johannessen H, Doeland B, Vo AAD, Dahl AF, Svendsen K, Thoresen M, Refsum H, Rising R, Barvikova K, van Greevenbroek M, Kozich V, Retterstol K, Vinknes KJ. Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial. J Transl Med. 2024 Jan 9;22(1):40. doi: 10.1186/s12967-023-04833-w.
Stolt E, Olsen T, Elshorbagy A, Kozich V, van Greevenbroek M, Ovrebo B, Thoresen M, Refsum H, Retterstol K, Vinknes KJ. Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements. J Transl Med. 2021 Apr 15;19(1):153. doi: 10.1186/s12967-021-02824-3.
Other Identifiers
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310475
Identifier Type: -
Identifier Source: org_study_id
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