Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
19 participants
INTERVENTIONAL
2018-10-08
2018-12-11
Brief Summary
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Detailed Description
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The overall aim of this project is to evaluate the effects of a diet low in methionine and cysteine on markers of lipids, amino acids, glucose and other biomarkers related to energy metabolism, including transcriptomic and protein expression data from adipose tissue and lymphocytes. Overweight and obese but otherwise healthy volunteers will be randomized to receive a diet either low, moderate or high in methionine and cysteine concentrations for 1 week.
This is a pilot study that may be considered an extension of NCT02647970. In addition to the primary and secondary outcomes we will evaluate the feasibility of the intervention and procedures.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Investigator: Randomization will be carried out by an investigator that is not related to the study. All foods will be pre-packaged and delivered to the participants by an unrelated company.
Study Groups
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Low met/cys diet
Dietary intervention
Low met/cys diet
Dietary intervention with low contents of methionine and cysteine
Moderate met/cys diet
Dietary intervention
Moderate met/cys diet
Dietary intervention with moderate contents of methionine and cysteine
High met/cys diet
Dietary intervention
High met/cys diet
Dietary intervention with high contents of methionine and cysteine
Interventions
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Low met/cys diet
Dietary intervention with low contents of methionine and cysteine
Moderate met/cys diet
Dietary intervention with moderate contents of methionine and cysteine
High met/cys diet
Dietary intervention with high contents of methionine and cysteine
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Smoking
* Drugs
* Chronic disease
* Pregnancy or breastfeeding
20 Years
40 Years
FEMALE
Yes
Sponsors
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The Research Council of Norway
OTHER
University of Oxford
OTHER
University of Oslo
OTHER
Responsible Party
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Kathrine Vinknes
Kathrine Vinknes, PhD
Locations
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University of Oslo
Oslo, , Norway
Countries
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References
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Olsen T, Ovrebo B, Haj-Yasein N, Lee S, Svendsen K, Hjorth M, Bastani NE, Norheim F, Drevon CA, Refsum H, Vinknes KJ. Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. J Transl Med. 2020 Mar 11;18(1):122. doi: 10.1186/s12967-020-02288-x.
Elshorbagy A, Bastani NE, Lee-Odegard S, Ovrebo B, Haj-Yasein N, Svendsen K, Turner C, Refsum H, Vinknes KJ, Olsen T. The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression. Amino Acids. 2023 Mar;55(3):313-323. doi: 10.1007/s00726-022-03229-2. Epub 2022 Dec 21.
Other Identifiers
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239948-B
Identifier Type: -
Identifier Source: org_study_id
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