Renal Functional Magnetic Resonance Imaging in Healthy Persons

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-15

Study Completion Date

2021-03-27

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main purpose of the study is to describe the applicability and reproducibility of functional MRI scans of the kidneys in healthy participants. Furthermore, the study examines to what extent physiological stress caused by lying in a scanner affects the renal perfusion and thus the reproducibility

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Test-retest Stability of MR-parameters. A Neuroimaging Pilot-study in Healthy Volunteers

NCT01239615

Magnetic Resonance

WITHDRAWN

Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects

NCT05604534

Normal Physiology

RECRUITING

Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners

NCT06884410

Multiparametric MRI

RECRUITING NA

Magnetization Transfer Quantitation and Characterization for Clinical Scanners

NCT00001714

Healthy

COMPLETED

Assessment of Renal Function by Multiparametric MRI

NCT06407375

Renal Impairment

COMPLETED EARLY_PHASE1

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

2 groups of 10 healthy participants each are included. 1 group aged 18 to 40 and a group of participants above 60 years of age.

The functional MRI sequences are performed consecutively in a protocol set up on a 1,5 T MRI scanner.

In totl, 3 identical scans are being performed. 2 scans on day 1 followed by another scan 1-2 weeks later. Before and after each scan, cortisol and copeptin is controlled in a blood sample to quantify the level of physiological stress.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Healthy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthy participants aged 18 to 40

3 identical functional MRI scans. Blood samples to quantify level of physiological stress are taken before and after each scan.

Functional MRI scan

Intervention Type DIAGNOSTIC_TEST

Functional MRI scan: Phase contrast, BOLD, Arterial Spin Labeling, Diffusion weighted MRI, T1 mapping, T1rho mapping

Healthy participants aged 60 and above

3 identical functional MRI scans. Blood samples to quantify level of physiological stress are taken before and after each scan.

Functional MRI scan

Intervention Type DIAGNOSTIC_TEST

Functional MRI scan: Phase contrast, BOLD, Arterial Spin Labeling, Diffusion weighted MRI, T1 mapping, T1rho mapping

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Functional MRI scan

Functional MRI scan: Phase contrast, BOLD, Arterial Spin Labeling, Diffusion weighted MRI, T1 mapping, T1rho mapping

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age between 18 and 40
* Age of 60 or above

Exclusion Criteria

* Known kidney or cardiovascular disease
* Medicine of any kind, that must be taken on days of scanning
* MRi incompatible implants or other contraindications to MRi
* Claustrophobia
* Not being able to lie still in an hour
* Body weight above 110 kg or waist circumference above 95 cm
* Pregnancy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes