MRI Assessment of Impaired Glucose Metabolism in Alzheimer's Disease
NCT ID: NCT05402566
Last Updated: 2023-12-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
21 participants
OBSERVATIONAL
2022-12-22
2023-10-27
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Healhy volunteers
Repeated MRI and DMI for simplification of protocols. Repeated within 6 +/- 2 weeks.
Deuterium metabolic imaging
MRI after oral administration of 75g of \[6,6'-2H2\]glucose.
Alzheimer's disease patients
MRI and DMI to assess cerebral glucose metabolism. Single examination. Compared with PET.
Deuterium metabolic imaging
MRI after oral administration of 75g of \[6,6'-2H2\]glucose.
Healthy controls
MRI and DMI for comparison with AD patients.
Deuterium metabolic imaging
MRI after oral administration of 75g of \[6,6'-2H2\]glucose.
Interventions
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Deuterium metabolic imaging
MRI after oral administration of 75g of \[6,6'-2H2\]glucose.
Eligibility Criteria
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Inclusion Criteria
* Aged 55-85 years.
* Male or female.
* AD diagnosis by the NIA-AA 2011 research criteria.8
* Able to give written informed consent.
* Mini-mental state examination (MMSE) equal to or above 18.9
* Brain FDG-PET performed at Aarhus University Hospital consistent with AD.
Healthy participants:
* Aged 18-85 years.
* Male or female.
Exclusion Criteria
* Diabetes or any other metabolic disease.
* Other significant brain disease:
* Strokes.
* Tumors.
* Chronic small vessel disease (clinically suspected, or Fazekas ≥ 2 if clinical MRI is available).
* Epilepsy.
* Other neurodegenerative or -inflammatory disease.
* Contraindications for MRI:
* Pacemaker, neurostimulator or cochlear implant.
* Metal foreign bodies such as fragments and irremovable piercings.
* Unsafe medical implants (safety of heart valves, hips and the like must be confirmed).
* Claustrophobia.
* Largest circumference including arms \> 160 cm.
* Pregnant - women must be post-menopausal or confirmed non-pregnant by an onsite test.
18 Years
85 Years
ALL
No
Sponsors
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Aarhus University Hospital
OTHER
University of Aarhus
OTHER
Responsible Party
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Locations
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Aarhus University
Aarhus, , Denmark
Countries
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References
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Bogh N, Vaeggemose M, Schulte RF, Hansen ESS, Laustsen C. Repeatability of deuterium metabolic imaging of healthy volunteers at 3 T. Eur Radiol Exp. 2024 Mar 13;8(1):44. doi: 10.1186/s41747-024-00426-4.
Other Identifiers
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DMI-AD
Identifier Type: -
Identifier Source: org_study_id