Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
450 participants
OBSERVATIONAL
2023-10-11
2027-11-30
Brief Summary
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Detailed Description
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Preliminary data indicate that global brain stiffness is highly reproducible and that Alzheimer's disease causes a decrease in brain stiffness when compared to age- and gender-matched cognitively normal controls. The purpose of the proposed work is to further investigate the potential of brain stiffness as a novel biomarker for Alzheimer's disease. A comparison between brain stiffness and existing Alzheimer's disease biomarkers will help determine the biological basis of the observed stiffness change and in time may improve the sensitivity of Alzheimer's disease diagnosis and grading.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Healthy Control Group
Subjects will have a magnetic resonance elastography (MRE) performed.
Magnetic Resonance Elastography (MRE)
Imaging technique performed on a Compact 3T MRI scanner that measures the stiffness (mechanical properties) of tissues.
Alzheimer's Disease Group
Subjects will have a magnetic resonance elastography (MRE) performed.
Magnetic Resonance Elastography (MRE)
Imaging technique performed on a Compact 3T MRI scanner that measures the stiffness (mechanical properties) of tissues.
Mild Cognitive Impairment Group
Subjects will have a magnetic resonance elastography (MRE) performed.
Magnetic Resonance Elastography (MRE)
Imaging technique performed on a Compact 3T MRI scanner that measures the stiffness (mechanical properties) of tissues.
Interventions
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Magnetic Resonance Elastography (MRE)
Imaging technique performed on a Compact 3T MRI scanner that measures the stiffness (mechanical properties) of tissues.
Eligibility Criteria
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Inclusion Criteria
* No Active neurological or psychiatric conditions, if a prior neurological or psychiatric condition was present they must have returned to normal
* No cognitive complaints
* Normal neurological examination
* No psychoactive medications
* They may have a chronic medical condition that does not affect cognition
* Low Aβ load Pittsburgh compound-B (PiB) ratio \<1.5
* In good general health
* Memory complaint documented by the patient and collateral source
* Normal general cognitive function as determined by measure of general intellectual function and screening including the Short Test of Mental Status
* Normal activities of daily living as documented by history and Record of Independent Living
* Not demented by DSM-III-R criteria
* Do have an objective memory impairment determined by the clinical judgement of the neuropsychologists and neurologists
* High Aβ load Pittsburgh compound-B (PiB) ratio ≥1.5
* In good general health
* Dementia not a result of other medical or psychiatric conditions
* Diagnosis of dementia made according to DSM-III-R criteria
* Do have objective memory impairment determined by the clinical judgement of the neuropsychologists and neurologists
* High Aβ load Pittsburgh compound-B (PiB) ratio ≥1.5
Exclusion Criteria
* Major depression
* History of primary or metastatic intracranial neoplasm, significant head trauma, intra-cerebral hemorrhage, hemispheric stroke
* Contradictions to MRI imaging including but not limited to cardiac pacemakers, intraocular or intracranial metal, or other MRI incompatible devices.
* Pregnant women. Women of child bearing potential will be given a urine pregnancy test prior the MRI scan. Results will be shared with the participant. If the pregnancy test is positive, the participant will not be included within the study
18 Years
100 Years
ALL
Yes
Sponsors
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National Institute on Aging (NIA)
NIH
Mayo Clinic
OTHER
Responsible Party
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John Huston
Principal Investigator
Principal Investigators
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John Huston, MD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic Minnesota
Rochester, Minnesota, United States
Countries
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Related Links
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Mayo Clinic Clinical Trials
Other Identifiers
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23-004125
Identifier Type: -
Identifier Source: org_study_id