A Validation Study of the German Autobiographical Memory Interview

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-15

Study Completion Date

2021-05-01

Brief Summary

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Electroconvulsive therapy (ECT) is recommended for the treatment of severe depression. But, despite the high remission rates the use of ECT is strongly limited by the social stigma and treatment-emergent cognitive side effects in patients. The most relevant is retrograde amnesia (RA), because it can persists for months and years. To measure RA after ECT the short-form of the Autobiographical Memory Interview (SF-AMI) is commonly used. However, the validation of the German SF-AMI has not yet been carried out. Thus, the aim of this study is to validate the German SF-AMI in depressed patient and healthy controls.

The investigators hypothesize that the German SF-AMI is reliable and valid to quantify RA.

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Detailed Description

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To measure retrograde amnesia of autobiographical memory after ECT, various tests were used so far. Currently, the short form of the Autobiographical Memory Interview (AMI-SF) was used most frequently internationally. In Germany there is no validated translation of the AMI-SF. However, in order to be able to systematically record the cognitive side effects of ECT in clinical practice as well as in research in the German-speaking area, it is important to have validated test procedures that can be successfully used in repeated measurements. In this study, the German version of the AMI (D-AMI), i.e. the specificity of the German short version of the autobiographical memory in patients with depression will be investigated. It is also known in healthy people that autobiographical memory contents can no longer be called up over time. Therefore, the aim of this study is to investigate whether a change in autobiographical memory over the course of time in depressed patients differs from healthy control subjects. It should also be shown whether this German short version for examining autobiographical memory (D-AMI) can be carried out.

Conditions

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Retrograde Amnesia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Patients with depression

* Major depression according to DSM-V and ICD-10 (ICD F32.1, F32.2, F32.3, F33.1, F33.2, F33.3)
* Hamilton Depression Rating Scale \> 17

Group Type ACTIVE_COMPARATOR

German Autobiographical Memory Interview short-form

Intervention Type DIAGNOSTIC_TEST

Diagnostic Test

Healthy controls

\- Mental health

Group Type ACTIVE_COMPARATOR

German Autobiographical Memory Interview short-form

Intervention Type DIAGNOSTIC_TEST

Diagnostic Test

Interventions

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German Autobiographical Memory Interview short-form

Diagnostic Test

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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D-AMI

Eligibility Criteria

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Inclusion Criteria

* MDD
* HDRS \> 17
* Age 18-80
* Ability to give informed consent

Exclusion Criteria

* Drugs or drug abuse or addictions
* Use of benzodiazepine equivalent to lorazepam\> 1.5 mg per day
* Cognitive impairments
* History of traumatic brain injury
* Relevant organic disease, e.g. Multiple sclerosis, Parkinson's disease
* Bipolar illness, dementia or schizophrenic disorder
* German is not the mother tongue
* Inability to give informed consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes