Effects of COVID-19 Induced Deconditioning After Long-term High Intensity Resistance Exercise

NCT ID: NCT04444661

Last Updated: 2021-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

21 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-10

Study Completion Date

2020-12-31

Brief Summary

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Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort.

The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.

Detailed Description

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Conditions

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Osteoporosis Sarcopenia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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HIT-resistance exercise

High Intensity Resistance Exercise

No interventions assigned to this group

Non exercising control

Control group that maintained life style and physical activity habits

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* participants of the FrOST study (NCT03453463)

Exclusion Criteria

* medication and diseases with potential impact on study outcomes during the last 26 weeks.
Minimum Eligible Age

74 Years

Maximum Eligible Age

95 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Friedrich-Alexander-Universität Erlangen-Nürnberg

OTHER

Sponsor Role collaborator

University of Erlangen-Nürnberg Medical School

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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wolfgang Kemmler, PhD

Role: PRINCIPAL_INVESTIGATOR

Institute of Medical Physics, Friedrich-Alexander University Erlangen-Nürnberg

Locations

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Institute of Medical Physics, Friedrich Alexander University Erlangen-Nürnberg

Erlangen, Bavaria, Germany

Site Status

Countries

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Germany

References

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Kemmler W, Kohl M, Frohlich M, Jakob F, Engelke K, von Stengel S, Schoene D. Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia-One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). J Bone Miner Res. 2020 Sep;35(9):1634-1644. doi: 10.1002/jbmr.4027. Epub 2020 Apr 28.

Reference Type BACKGROUND
PMID: 32270891 (View on PubMed)

Lichtenberg T, von Stengel S, Sieber C, Kemmler W. The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study. Clin Interv Aging. 2019 Dec 16;14:2173-2186. doi: 10.2147/CIA.S225618. eCollection 2019.

Reference Type BACKGROUND
PMID: 31908428 (View on PubMed)

Kemmler W, Kohl M, Frohlich M, Schoene D, von Stengel S. Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Bone. 2021 Jan;142:115772. doi: 10.1016/j.bone.2020.115772. Epub 2020 Nov 26.

Reference Type DERIVED
PMID: 33249320 (View on PubMed)

Other Identifiers

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FrOST-FU

Identifier Type: -

Identifier Source: org_study_id

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